全身 FDG PET/MR 图谱用于多参数体素基于分析。
A whole-body FDG PET/MR atlas for multiparametric voxel-based analysis.
机构信息
Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Department of Information Technology, Uppsala University, Uppsala, Sweden.
出版信息
Sci Rep. 2019 Apr 16;9(1):6158. doi: 10.1038/s41598-019-42613-z.
Quantitative multiparametric imaging is a potential key application for Positron Emission Tomography/Magnetic Resonance (PET/MR) hybrid imaging. To enable objective and automatic voxel-based multiparametric analysis in whole-body applications, the purpose of this study was to develop a multimodality whole-body atlas of functional 18F-fluorodeoxyglucose (FDG) PET and anatomical fat-water MR data of adults. Image registration was used to transform PET/MR images of healthy control subjects into male and female reference spaces, producing a fat-water MR, local tissue volume and FDG PET whole-body normal atlas consisting of 12 male (66.6 ± 6.3 years) and 15 female (69.5 ± 3.6 years) subjects. Manual segmentations of tissues and organs in the male and female reference spaces confirmed that the atlas contained adequate physiological and anatomical values. The atlas was applied in two anomaly detection tasks as proof of concept. The first task automatically detected anomalies in two subjects with suspected malignant disease using FDG data. The second task successfully detected abnormal liver fat infiltration in one subject using fat fraction data.
定量多参数成像是正电子发射断层扫描/磁共振（PET/MR）混合成像的潜在关键应用。为了在全身应用中实现客观和自动的基于体素的多参数分析，本研究旨在开发成人功能性 18F-氟脱氧葡萄糖（FDG）PET 和解剖性脂肪-水 MR 数据的多模态全身图谱。图像配准用于将健康对照者的 PET/MR 图像转换为男性和女性参考空间，生成由 12 名男性（66.6±6.3 岁）和 15 名女性（69.5±3.6 岁）组成的脂肪-水 MR、局部组织体积和 FDG PET 全身正常图谱。对男性和女性参考空间中组织和器官的手动分割证实，图谱包含足够的生理和解剖学值。该图谱在两个异常检测任务中得到了应用，作为概念验证。第一项任务使用 FDG 数据自动检测了两名疑似恶性疾病患者的异常。第二项任务成功使用脂肪分数数据检测了一名患者的异常肝脂肪浸润。
Zotero 插件