Kim Jooyoung, So Wi-Young
College of Physical Education, Kookmin University, Seoul, Republic of Korea.
Sports and Health Care Major, College of Humanities and Arts, Korea National University of Transportation, Chungju-si, Republic of Korea.
J Exerc Sci Fit. 2019 Jan 20;17(2):77-79. doi: 10.1016/j.jesf.2019.01.001. Epub 2019 Jan 3.
BACKGROUND/OBJECTIVE: High intensity eccentric exercise causes muscle damage. Polyphenol supplementation is one nutritional intervention available to limit muscle damage, but there is a lack of published data concerning the use of polyphenol-rich grape seed extract (GSE). This study investigated the effect of acute GSE supplementation on muscle damage markers after eccentric exercise.
Sixteen healthy male university students (mean age: 20.3 ± 0.4 years, height: 176.1 ± 4.7 cm, weight: 69.9 ± 10.2 kg) were included. Participants were randomly assigned to GSE group (n = 8) or placebo group (n = 8); 300 mg/day of GSE or placebo was consumed from the time of eccentric exercise to 72 h after exercise. For the eccentric exercise, the elbow flexor muscle was activated using a modified preacher curl machine at 25 repetitions for 2 sets. For the muscle damage markers, maximal muscle strength, muscle soreness, and creatine kinase (CK) level were measured.
There was no difference in maximal muscle strength and muscle soreness between groups in the recovery stage after eccentric exercise (p > 0.05); CK level, a marker of cell membrane damage, was significantly decreased 96 h after exercise in the GSE group compared with the placebo group (p < 0.05).
Acute GSE supplement can be an effective way to decrease cellular membrane damage after eccentric exercise. These results could be helpful in the application of GSE supplementation as a nutritional intervention to reduce muscle damage after high intensity strength training, especially in the early stage of a new strength training program. However, a larger scale study is necessary to validate these results.
背景/目的：高强度离心运动可导致肌肉损伤。补充多酚是一种可用于限制肌肉损伤的营养干预措施，但关于使用富含多酚的葡萄籽提取物（GSE）的公开数据较少。本研究调查了急性补充GSE对离心运动后肌肉损伤标志物的影响。
纳入16名健康男性大学生（平均年龄：20.3±0.4岁，身高：176.1±4.7厘米，体重：69.9±10.2千克）。参与者被随机分为GSE组（n = 8）或安慰剂组（n = 8）；从离心运动时起至运动后72小时，每天服用300毫克GSE或安慰剂。对于离心运动，使用改良的牧师椅弯举机激活肘屈肌，进行2组，每组25次重复。对于肌肉损伤标志物，测量最大肌肉力量、肌肉酸痛和肌酸激酶（CK）水平。
离心运动后恢复阶段，两组之间的最大肌肉力量和肌肉酸痛无差异（p>0.05）；与安慰剂组相比，GSE组运动后96小时时，作为细胞膜损伤标志物的CK水平显著降低（p<0.05）。
急性补充GSE可能是减少离心运动后细胞膜损伤的有效方法。这些结果可能有助于将GSE补充剂作为一种营养干预措施应用于减少高强度力量训练后的肌肉损伤，尤其是在新的力量训练计划的早期阶段。然而，需要更大规模的研究来验证这些结果。
