通过机械化学合成酰基甘油衍生物。
Synthesis of acylglycerol derivatives by mechanochemistry.
作者信息
Ardila-Fierro Karen J, Pich Andrij, Spehr Marc, Hernández José G, Bolm Carsten
机构信息
Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, D-52074 Aachen, Germany.
Functional and Interactive Polymers, Institute of Technical and Macromolecular Chemistry, RWTH Aachen University, Worringerweg 2, 52074 Aachen, Germany.
出版信息
Beilstein J Org Chem. 2019 Mar 29;15:811-817. doi: 10.3762/bjoc.15.78. eCollection 2019.
In recent times, many biologically relevant building blocks such as amino acids, peptides, saccharides, nucleotides and nucleosides, etc. have been prepared by mechanochemical synthesis. However, mechanosynthesis of lipids by ball milling techniques has remained essentially unexplored. In this work, a multistep synthetic route to access mono- and diacylglycerol derivatives by mechanochemistry has been realized, including the synthesis of diacylglycerol-coumarin conjugates.
近年来，许多具有生物学相关性的结构单元，如氨基酸、肽、糖类、核苷酸和核苷等，已通过机械化学合成法制备出来。然而，通过球磨技术对脂质进行机械合成基本上仍未得到探索。在这项工作中，已经实现了一条通过机械化学合成单酰甘油和二酰甘油衍生物的多步合成路线，包括二酰甘油 - 香豆素共轭物的合成。
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