氨基磺酸促进的一锅多组分反应：在球磨条件下简便合成4-氧代四氢吲哚。

Sulfamic acid promoted one-pot multicomponent reaction: a facile synthesis of 4-oxo-tetrahydroindoles under ball milling conditions.

作者信息

Lambat Trimurti L, Abdala Ahmed A, Mahmood Sami, Ledade Pankaj V, Chaudhary Ratiram G, Banerjee Subhash

机构信息

Department of Chemistry, Manoharbhai Patel College of Arts, Commerce & Science Deori Dist-Gondia 441901 Maharashtra India

Chemical Engineering Program, Texas A & M University at Qatar POB 23784 Doha Qatar.

出版信息

RSC Adv. 2019 Dec 3;9(68):39735-39742. doi: 10.1039/c9ra08478a. eCollection 2019 Dec 2.

We report an efficient and facile one-pot synthesis of 4-oxo-tetrahydroindoles using sulfamic acid under ball milling conditions. The present protocol for preparation of biologically important 4-oxo-tetrahydroindoles offers several advantages such as mild reaction conditions, improved selectivity and higher isolated yields. Moreover, solvent-free reaction conditions and the use of ball milling make the present protocol environmentally friendly in nature.