CON ("The window is closed"): In patients with cirrhosis with ascites, the clinical risks of nonselective beta-blocker outweigh the benefits and should NOT be prescribed.
作者信息
Aday Ariel W, Rich Nicole E, Mufti Arjmand R, Tujios Shannan R
机构信息
Department of Internal Medicine, Division of Digestive and Liver Diseases UT Southwestern Medical Center Dallas TX.
出版信息
Clin Liver Dis (Hoboken). 2018 Jun 5;11(5):123-127. doi: 10.1002/cld.699. eCollection 2018 May.
Abstract
摘要
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CON ("The window is closed"): In patients with cirrhosis with ascites, the clinical risks of nonselective beta-blocker outweigh the benefits and should NOT be prescribed.禁忌（“窗户关闭”）：在肝硬化腹水患者中，非选择性β受体阻滞剂的临床风险大于益处，不应开具此类药物。
Clin Liver Dis (Hoboken). 2018 Jun 5;11(5):123-127. doi: 10.1002/cld.699. eCollection 2018 May.
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Stratifying risk in the prevention of recurrent variceal hemorrhage: Results of an individual patient meta-analysis.预防复发性静脉曲张出血的风险分层：一项个体患者荟萃分析的结果
Hepatology. 2017 Oct;66(4):1219-1231. doi: 10.1002/hep.29267. Epub 2017 Aug 26.
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Beneficial and harmful effects of nonselective beta blockade on acute kidney injury in liver transplant candidates.非选择性β受体阻滞剂对肝移植候选者急性肾损伤的有益和有害影响。
Liver Transpl. 2017 Jun;23(6):733-740. doi: 10.1002/lt.24744.
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Effect of propranolol on survival in patients with decompensated cirrhosis: a nationwide study based Danish patient registers.普萘洛尔对失代偿期肝硬化患者生存率的影响：一项基于丹麦全国患者登记系统的研究
Liver Int. 2016 Sep;36(9):1304-12. doi: 10.1111/liv.13119. Epub 2016 Apr 4.
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Gut. 2016 Jul;65(7):1228-30. doi: 10.1136/gutjnl-2016-311527. Epub 2016 Mar 2.
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Treatment with non-selective beta blockers is associated with reduced severity of systemic inflammation and improved survival of patients with acute-on-chronic liver failure.非选择性β受体阻滞剂治疗与降低慢加急性肝衰竭患者全身炎症反应严重程度和改善患者生存相关。
J Hepatol. 2016 Mar;64(3):574-82. doi: 10.1016/j.jhep.2015.10.018. Epub 2015 Oct 28.
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Non-selective β-blockers are associated with improved survival in patients with ascites listed for liver transplantation.非选择性β受体阻滞剂可改善等待肝移植患者腹水的生存率。
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