肾损伤分子1（KIM-1）作为心脏直视手术患者体外循环（CPB）后急性肾损伤的早期预测指标。
Kidney Injury Molecule 1 (KIM-1) as an Early Predictor for Acute Kidney Injury in Post-Cardiopulmonary Bypass (CPB) in Open Heart Surgery Patients.
作者信息
Khreba Nora A, Abdelsalam Mostafa, Wahab A M, Sanad Mohammed, Elhelaly Rania, Adel Mohammed, El-Kannishy Ghada
机构信息
Mansoura Nephrology and Dialysis Unit, Internal Medicine Department, Mansoura University, Egypt.
Cardiothoracic Surgery Department, Mansoura University, Egypt.
出版信息
Int J Nephrol. 2019 Mar 12;2019:6265307. doi: 10.1155/2019/6265307. eCollection 2019.
INTRODUCTION
Postoperative acute kidney injury is associated with a higher mortality, a more complicated hospital course with longer hospital stay. Urinary kidney injury molecule 1 may play an important role as an early predictor of acute kidney injury post-cardiopulmonary in open heart surgery.
METHODS
We evaluated 45 patients who underwent open heart surgery from January 2016 to June 2016. Both urinary kidney injury molecule 1 and serum creatinine were evaluated before operation and 3hs and 24hs after operation. Acute kidney injury was diagnosed according to Kidney Disease: Improving Global Outcomes, 2012 guidelines.
RESULTS
In this study, 27 patients developed acute kidney injury. The three hour-post-surgery urinary kidney injury molecule 1 was significantly higher in the acute kidney injury group (P<0.015) and, at the same time, we did not find any significant difference in the serum creatinine levels between the two groups.
CONCLUSION
Although serum creatinine is still the gold standard for diagnosis of acute kidney injury searching for other new markers is mandatory. Urinary kidney injury molecule 1 can be used as simple noninvasive and specific biomarker for early diagnosis of acute kidney injury.
引言
术后急性肾损伤与更高的死亡率相关，会导致住院过程更复杂，住院时间更长。尿肾损伤分子1可能作为心脏直视手术中心肺转流术后急性肾损伤的早期预测指标发挥重要作用。
方法
我们评估了2016年1月至2016年6月期间接受心脏直视手术的45例患者。在手术前、术后3小时和24小时对尿肾损伤分子1和血清肌酐进行评估。根据《肾脏病：改善全球预后》2012版指南诊断急性肾损伤。
结果
在本研究中，27例患者发生急性肾损伤。急性肾损伤组术后3小时尿肾损伤分子1显著更高（P<0.015），同时，我们未发现两组血清肌酐水平有任何显著差异。
结论
尽管血清肌酐仍是诊断急性肾损伤的金标准，但寻找其他新标志物是必要的。尿肾损伤分子1可作为早期诊断急性肾损伤的简单、无创且特异的生物标志物。
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