• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Antibiotics-From There to Where?: How the antibiotic miracle is threatened by resistance and a broken market and what we can do about it.

作者信息

Shlaes David M, Bradford Patricia A

机构信息

Anti-infectives Consulting (retired), Stonington, Connecticut.

Antimicrobial Development Specialists, LLC, Nyack, New York.

出版信息

Pathog Immun. 2018 Feb 22;3(1):19-43. doi: 10.20411/pai.v3i1.231. eCollection 2018.

DOI:10.20411/pai.v3i1.231
PMID:30993248
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6423724/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b10/6423724/0057ec2cbbe6/pai-3-019-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b10/6423724/741fbf9455f2/pai-3-019-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b10/6423724/5b810bfa56d9/pai-3-019-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b10/6423724/fd598a18ea45/pai-3-019-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b10/6423724/67b101ab62ef/pai-3-019-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b10/6423724/0057ec2cbbe6/pai-3-019-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b10/6423724/741fbf9455f2/pai-3-019-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b10/6423724/5b810bfa56d9/pai-3-019-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b10/6423724/fd598a18ea45/pai-3-019-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b10/6423724/67b101ab62ef/pai-3-019-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b10/6423724/0057ec2cbbe6/pai-3-019-g005.jpg

相似文献

1
Antibiotics-From There to Where?: How the antibiotic miracle is threatened by resistance and a broken market and what we can do about it.抗生素——从何而来，走向何方？：抗生素奇迹如何受到耐药性和失灵市场的威胁以及我们对此能做些什么。
Pathog Immun. 2018 Feb 22;3(1):19-43. doi: 10.20411/pai.v3i1.231. eCollection 2018.
2
Antibiotic Potentiation as a Promising Strategy to Combat Macrolide Resistance in Bacterial Pathogens.抗生素增效作为对抗细菌病原体大环内酯类耐药性的一种有前景的策略。
Antibiotics (Basel). 2023 Dec 11;12(12):1715. doi: 10.3390/antibiotics12121715.
3
The beginning of the end of the antibiotic era? Part II. Proposed solutions to antibiotic abuse.抗生素时代终结的开端？第二部分。抗生素滥用问题的建议解决方案。
Quintessence Int. 1998 Apr;29(4):223-9.
4
Prevention of infective endocarditis and bacterial resistance to antibiotics: A brief review.感染性心内膜炎的预防及细菌对抗生素的耐药性：简要综述。
Spec Care Dentist. 2019 Nov;39(6):603-609. doi: 10.1111/scd.12415. Epub 2019 Aug 28.
5
Benefits of Combined Phage-Antibiotic Therapy for the Control of Antibiotic-Resistant Bacteria: A Literature Review.联合噬菌体-抗生素疗法控制耐药菌的益处：文献综述
Antibiotics (Basel). 2022 Jun 22;11(7):839. doi: 10.3390/antibiotics11070839.
6
The Assessment of Antimicrobial Resistance in Gram-Negative and Gram-Positive Infective Endocarditis: A Multicentric Retrospective Analysis.革兰氏阴性和革兰氏阳性感染性心内膜炎的抗菌药物耐药评估：一项多中心回顾性分析。
Medicina (Kaunas). 2023 Feb 24;59(3):457. doi: 10.3390/medicina59030457.
7
Endocarditis Antibiotic Regimens心内膜炎抗生素治疗方案
8
[Progress in strategies to combat antimicrobial resistance].[对抗抗菌药物耐药性策略的进展]
Sheng Wu Gong Cheng Xue Bao. 2018 Aug 25;34(8):1346-1360. doi: 10.13345/j.cjb.180223.
9
Treatment of Gram-negative pneumonia in the critical care setting: is the beta-lactam antibiotic backbone broken beyond repair?重症监护环境下革兰氏阴性菌肺炎的治疗：β-内酰胺类抗生素的核心地位是否已无法修复？
Crit Care. 2016 Jan 29;20:19. doi: 10.1186/s13054-016-1197-5.
10
Integron activity accelerates the evolution of antibiotic resistance.整合子活性加速了抗生素耐药性的进化。
Elife. 2021 Feb 26;10:e62474. doi: 10.7554/eLife.62474.

引用本文的文献

1
Characterization and Biofilm Inhibition of Multidrug-Resistant Isolates.多重耐药菌株的特性鉴定与生物膜抑制
Int J Microbiol. 2024 Dec 28;2024:5749982. doi: 10.1155/ijm/5749982. eCollection 2024.
2
Comparison of nasopharyngeal bacteriological profile between patients with diabetes and healthy individuals in Accra, Ghana.加纳阿克拉糖尿病患者与健康个体鼻咽部细菌学特征比较
BMC Res Notes. 2024 Dec 19;17(1):362. doi: 10.1186/s13104-024-07003-3.
3
Deciphering Antibiotic-Targeted Metabolic Pathways in : Insights from Transcriptomics and Genome-Scale Metabolic Modeling.

本文引用的文献

1
ECDC/EFSA/EMA second joint report on the integrated analysis of the consumption of antimicrobial agents and occurrence of antimicrobial resistance in bacteria from humans and food-producing animals: Joint Interagency Antimicrobial Consumption and Resistance Analysis (JIACRA) Report.欧洲疾病预防控制中心/欧洲食品安全局/欧洲药品管理局关于人类和食用动物源细菌中抗菌药物消费及抗菌药物耐药性发生情况综合分析的第二次联合报告：跨部门抗菌药物消费与耐药性联合分析（JIACRA）报告
EFSA J. 2017 Jul 27;15(7):e04872. doi: 10.2903/j.efsa.2017.4872. eCollection 2017 Jul.
2
Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis.发现、研究和开发新抗生素：世界卫生组织抗微生物药物耐药性和结核病优先病原体清单。
Lancet Infect Dis. 2018 Mar;18(3):318-327. doi: 10.1016/S1473-3099(17)30753-3. Epub 2017 Dec 21.
3
解读抗生素靶向的代谢途径：转录组学和基因组规模代谢建模的见解
Life (Basel). 2024 Sep 2;14(9):1102. doi: 10.3390/life14091102.
4
In Vitro and In Vivo Studies on a Mononuclear Ruthenium Complex Reveals It is a Highly Effective, Fast-Acting, Broad-Spectrum Antimicrobial in Physiologically Relevant Conditions.在生理相关条件下，单核钌配合物的体外和体内研究表明其具有高效、快速、广谱的抗菌作用。
ACS Infect Dis. 2024 Sep 13;10(9):3346-3357. doi: 10.1021/acsinfecdis.4c00447. Epub 2024 Aug 6.
5
Bioaerosol Sampling Devices and Pretreatment for Bacterial Characterization: Theoretical Differences and a Field Experience in a Wastewater Treatment Plant.用于细菌特征分析的生物气溶胶采样装置及预处理：理论差异与污水处理厂的现场经验
Microorganisms. 2024 May 10;12(5):965. doi: 10.3390/microorganisms12050965.
6
Lactate metabolism promotes in vivo fitness during Acinetobacter baumannii infection.乳酸代谢促进鲍曼不动杆菌感染期间的体内适应性。
FEMS Microbiol Lett. 2024 Jan 9;371. doi: 10.1093/femsle/fnae032.
7
Differential proteomic analysis and pathogenic effects of outer membrane vesicles derived from Acinetobacter baumannii under normoxia and hypoxia.需氧和缺氧条件下鲍曼不动杆菌外膜囊泡的差异蛋白质组学分析及致病作用。
PLoS One. 2023 Mar 15;18(3):e0283109. doi: 10.1371/journal.pone.0283109. eCollection 2023.
8
Clearing an ESKAPE Pathogen in a Model Organism; A Polypyridyl Ruthenium(II) Complex Theranostic that Treats a Resistant Acinetobacter baumannii Infection in Galleria mellonella.在模式生物中清除 ESKAPE 病原体；一种治疗粘质沙雷氏菌感染的多吡啶钌（II）配合物治疗剂在大蜡螟中的应用。
Chemistry. 2023 Feb 21;29(11):e202203555. doi: 10.1002/chem.202203555. Epub 2023 Jan 12.
9
Antibacterial Activities of Monsonia Angustifolia and Momordica Balsamina Linn Extracts against Carbapenem-Resistant Acinetobacter Baumannii.狭叶蒙索草和苦瓜提取物对耐碳青霉烯鲍曼不动杆菌的抗菌活性
Plants (Basel). 2022 Sep 12;11(18):2374. doi: 10.3390/plants11182374.
10
In Vitro Antimicrobial Activity of the Siderophore Cephalosporin Cefiderocol against Strains Recovered from Clinical Samples.铁载体头孢菌素头孢地尔对临床样本分离菌株的体外抗菌活性
Antibiotics (Basel). 2021 Oct 27;10(11):1309. doi: 10.3390/antibiotics10111309.
Colistin Versus Ceftazidime-Avibactam in the Treatment of Infections Due to Carbapenem-Resistant Enterobacteriaceae.多黏菌素与头孢他啶-阿维巴坦治疗碳青霉烯类耐药肠杆菌科细菌感染。
Clin Infect Dis. 2018 Jan 6;66(2):163-171. doi: 10.1093/cid/cix783.
4
Progress in the Fight Against Multidrug-Resistant Bacteria 2005-2016: Modern Noninferiority Trial Designs Enable Antibiotic Development in Advance of Epidemic Bacterial Resistance.2005-2016 年对抗多药耐药菌的进展：现代非劣效性试验设计使抗生素在细菌耐药性流行之前得以开发。
Clin Infect Dis. 2017 Jul 1;65(1):141-146. doi: 10.1093/cid/cix246.
5
Pull Incentives for Antibacterial Drug Development: An Analysis by the Transatlantic Task Force on Antimicrobial Resistance.推动抗菌药物研发的激励措施：抗微生物药物耐药性跨大西洋工作组的分析。
Clin Infect Dis. 2017 Oct 15;65(8):1378-1382. doi: 10.1093/cid/cix526.
6
Time for a change in how new antibiotics are reimbursed: Development of an insurance framework for funding new antibiotics based on a policy of risk mitigation.新抗生素报销方式的变革时机已到：基于风险缓解政策，为新抗生素开发筹资的保险框架。
Health Policy. 2017 Oct;121(10):1025-1030. doi: 10.1016/j.healthpol.2017.07.011. Epub 2017 Aug 5.
7
Antimicrobial Susceptibility Trends among Staphylococcus aureus Isolates from U.S. Hospitals: Results from 7 Years of the Ceftaroline (AWARE) Surveillance Program, 2010 to 2016.美国医院金黄色葡萄球菌分离株的抗菌药物敏感性趋势：2010 年至 2016 年头孢洛林（AWARE）监测计划的 7 年结果。
Antimicrob Agents Chemother. 2017 Aug 24;61(9). doi: 10.1128/AAC.01043-17. Print 2017 Sep.
8
Predictive compound accumulation rules yield a broad-spectrum antibiotic.预测性化合物积累规则产生一种广谱抗生素。
Nature. 2017 May 18;545(7654):299-304. doi: 10.1038/nature22308. Epub 2017 May 10.
9
The antibiotic pipeline: reviving research and development and speeding drugs to market.抗生素研发渠道：重振研发并加速药物上市
Expert Rev Anti Infect Ther. 2017 May;15(5):425-433. doi: 10.1080/14787210.2017.1308251. Epub 2017 Mar 29.
10
Molecular characterization of methicillin-resistant Staphylococcus aureus isolated from blood in Rio de Janeiro displaying susceptibility profiles to non-β-lactam antibiotics.从里约热内卢血液中分离出的对非β-内酰胺类抗生素呈现药敏谱的耐甲氧西林金黄色葡萄球菌的分子特征分析
Braz J Microbiol. 2017 Apr-Jun;48(2):237-241. doi: 10.1016/j.bjm.2016.09.016. Epub 2016 Dec 21.