Bernasconi Odette J, Donà Valentina, Tinguely Regula, Endimiani Andrea
Institute for Infectious Diseases, University of Bern, Bern, Switzerland.
Graduate School of Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland.
Pathog Immun. 2018 May 29;3(1):72-81. doi: 10.20411/pai.v3i1.234. eCollection 2018.
and spp. are 2 of the most frequent and deadly enteric bacterial pathogens recorded worldwide. In developing countries infections are responsible for many deaths annually and these mortality rates are prone to increase due to the emergence of resistance to antibiotics. In this overall scenario new alternative therapeutic approaches are needed.
For the first time, we investigated the activity of 3 commercial bacteriophage cocktails () against a collection of contemporary spp. (n = 30) and spp. (n = 20) strains isolated in Switzerland. Phage susceptibility was determined by implementing the spot test.
The overall susceptibility of spp. to and was 87% and 77%, respectively. With regard to spp., the overall susceptibility to and was 95% and 55%, respectively. was observed to be active against only 10% of spp. but against 95% of spp.
Our results seem promising, especially for the biopreparation against infections. Nevertheless, such speculation should be supported by further studies to confirm efficacy and safety of the cocktails. We also emphasize the importance of large screening analyses aimed to assess the activity of such biopreparations against contemporary multidrug-resistant strains that are emerging worldwide.
[细菌名称1]和[细菌名称2]是全球记录的最常见且致命的两种肠道细菌病原体。在发展中国家，[细菌名称1]感染每年导致许多人死亡，并且由于对抗生素耐药性的出现，这些死亡率有上升趋势。在这种总体情况下，需要新的替代治疗方法。
我们首次研究了3种商业噬菌体鸡尾酒制剂（[制剂名称]）对瑞士分离出的一组当代[细菌名称1]菌株（n = 30）和[细菌名称2]菌株（n = 20）的活性。通过斑点试验确定噬菌体敏感性。
[细菌名称1]对[噬菌体名称1]和[噬菌体名称2]的总体敏感性分别为87%和77%。对于[细菌名称2]，对[噬菌体名称1]和[噬菌体名称2]的总体敏感性分别为95%和55%。观察到[噬菌体名称3]仅对10%的[细菌名称1]菌株有活性，但对95%的[细菌名称2]菌株有活性。
我们的结果似乎很有前景，特别是对于针对[细菌名称1]感染的[生物制剂名称]。然而，这种推测应得到进一步研究的支持，以确认鸡尾酒制剂的疗效和安全性。我们还强调了大规模筛选分析的重要性，旨在评估此类生物制剂对全球正在出现的当代多重耐药菌株的活性。
