Hayashi S, Park M K, Kuehl T J
Prostaglandins. 1986 Oct;32(4):587-96. doi: 10.1016/0090-6980(86)90040-7.
Effects of prostaglandins (PGs) E1, E2, F2 alpha and I2 in a wide range of concentration were examined in mesenteric and cerebral arteries isolated from mature baboons. PGs E1, E2 and F2 alpha at low concentrations (10(-10) to 10(-7) M) elicited relaxation in helically cut strips of cerebral arteries precontracted with phenylephrine. In contrast, the PGs did not cause relaxation in the mesenteric artery. PGI2 (10(-9) to 10(-6) M) produced marked relaxation in both arteries. The EC25 for PGI2 in the mesenteric artery was significantly lower than that in the cerebral artery. During baseline conditions, cerebral arteries contracted in response to high concentrations (greater than 10(-7) M) of PGs E1, E2 and F2 alpha. In mesenteric arteries, a large contraction was induced by PGs F2 alpha and E2 but not by PGE1. Arachidonic acid (10(-6) M) produced an aspirin-inhibitable relaxation in both arteries to a similar extent, so that the vasodilator PG(s) formed in the two different arterial walls appear to exert a similar relaxant action. Thus, the baboon mesenteric artery was more sensitive to PGI2 for the relaxant effect than was the cerebral artery, while PGs F2 alpha, E1 and E2 caused only a contraction in the mesenteric artery but both relaxation and contraction in the cerebral artery.
研究了前列腺素（PGs）E1、E2、F2α和I2在广泛浓度范围内对从成年狒狒分离出的肠系膜动脉和脑动脉的影响。低浓度（10^(-10)至10^(-7)M）的PGs E1、E2和F2α可使预先用去氧肾上腺素预收缩的脑动脉螺旋条松弛。相比之下，这些PGs在肠系膜动脉中并未引起松弛。PGI2（10^(-9)至10^(-6)M）在两条动脉中均产生明显的松弛作用。PGI2在肠系膜动脉中的EC25显著低于脑动脉。在基线条件下，脑动脉对高浓度（大于10^(-7)M）的PGs E1、E2和F2α会发生收缩。在肠系膜动脉中，PGs F2α和E2可诱导强烈收缩，但PGE1则不会。花生四烯酸（10^(-6)M）在两条动脉中产生的阿司匹林可抑制的松弛程度相似，因此在两种不同动脉壁中形成的血管舒张性PG似乎发挥相似的舒张作用。因此，狒狒肠系膜动脉对PGI2的舒张作用比脑动脉更敏感，而PGs F2α、E1和E2在肠系膜动脉中仅引起收缩，在脑动脉中则既引起松弛又引起收缩。
