应用阿司匹林和聚磷酸根皮苷后分离的犬脑动脉和外周动脉对前列腺素的反应。

Responses of isolated dog cerebral and peripheral arteries to prostaglandins after application of aspirin and polyphloretin phosphate.

作者信息

Toda N, Miyazaki M

出版信息

Stroke. 1978 Sep-Oct;9(5):490-8. doi: 10.1161/01.str.9.5.490.

DOI:10.1161/01.str.9.5.490

Abstract

In helically cut strips of dog cerebral, coronary, mesenteric and femoral arteries, the contractile response to prostaglandin (PG) F2alpha, and E2, relative to contractions induced by 30 mM K+, did not appreciably differ, whereas relaxations induced by PGE1 relative to those induced by 10(-4) M papaverine were significantly different; the least in cerebral arteries and the greatest in mesenteric arteries. The relaxation of human cerebral arteries in response to PGE1 was similar to that of dog cerebral arteries. Treatment for 60 min with polyphloretin phosphate (3 X 10(-5) and 10(-4) g/ml) suppressed the contractile response to PGF2alpha and E2 but did not alter the response to 25 mM K+. The relaxing effect of PGE1 was not influenced. Aspirin (5 X 10(-5) and 2 X 10(-4) M) significantly potentiated the contractile response to PGF2alpha and E2 but did not alter the relaxation induced by PGE1. In contrast, contractions induced by serotonin were attenuated. It is concluded that dog cerebral, coronary, mesenteric and femoral arteries relaxed differently in response to PGE1. It appears that arterial responses to vasoconstricting PGs, but not to the vasodilating PG, are significantly attenuated by polyphloretin phosphate and potentiated by aspirin.

摘要

在犬脑动脉、冠状动脉、肠系膜动脉和股动脉的螺旋形切割条带中，前列腺素（PG）F2α和E2引起的收缩反应相对于30 mM K⁺诱导的收缩反应没有明显差异，而PGE1引起的舒张反应相对于10⁻⁴ M罂粟碱诱导的舒张反应则有显著差异；在脑动脉中最小，在肠系膜动脉中最大。人脑血管对PGE1的舒张反应与犬脑动脉相似。用聚磷酸根皮素（3×10⁻⁵和10⁻⁴ g/ml）处理60分钟可抑制对PGF2α和E2的收缩反应，但不改变对25 mM K⁺的反应。PGE1的舒张作用不受影响。阿司匹林（5×10⁻⁵和2×10⁻⁴ M）显著增强了对PGF2α和E2的收缩反应，但不改变PGE1诱导的舒张反应。相比之下，5-羟色胺诱导的收缩减弱。结论是，犬脑动脉、冠状动脉、肠系膜动脉和股动脉对PGE1的舒张反应不同。似乎聚磷酸根皮素可显著减弱动脉对血管收缩性PGs的反应，但不影响对血管舒张性PG的反应，而阿司匹林则增强这种反应。