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炔丙醇的区域选择性反式碳硼化反应

Regioselective trans-Carboboration of Propargyl Alcohols.

作者信息

Jin Hongming, Fürstner Alois

机构信息

Max-Planck-Institut für Kohlenforschung , 45470 Mülheim/Ruhr , Germany.

出版信息

Org Lett. 2019 May 3;21(9):3446-3450. doi: 10.1021/acs.orglett.9b01225. Epub 2019 Apr 17.

DOI:10.1021/acs.orglett.9b01225
PMID:30993987
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6727597/
Abstract

Proper choice of the base allowed trans-diboration of propargyl alcohols with B(pin) to evolve into an exquisitely regioselective procedure for net trans-carboboration. The method is modular as to the newly introduced carbon substituent (aryl, methyl, allyl, benzyl, alkynyl), which is invariably placed distal to the -OH group.

摘要

合适碱的选择使得炔丙醇与B(pin)的反式双硼化反应发展成为一种用于净反式碳硼化的高度区域选择性方法。就新引入的碳取代基（芳基、甲基、烯丙基、苄基、炔基）而言，该方法具有模块化特点，这些取代基总是位于-OH基团的远端。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bee/6727597/5da01759d5b8/ol-2019-01225g_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bee/6727597/18dd2f7f11f5/ol-2019-01225g_0004.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bee/6727597/1505cd1e71df/ol-2019-01225g_0006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bee/6727597/4dd3281a6fe1/ol-2019-01225g_0002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bee/6727597/126c358439a8/ol-2019-01225g_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bee/6727597/5da01759d5b8/ol-2019-01225g_0008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bee/6727597/ba14599c984c/ol-2019-01225g_0005.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bee/6727597/fce3d5d3a72b/ol-2019-01225g_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bee/6727597/126c358439a8/ol-2019-01225g_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1bee/6727597/5da01759d5b8/ol-2019-01225g_0008.jpg

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