Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, United Kingdom.
Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Am J Trop Med Hyg. 2019 Jun;100(6):1498-1506. doi: 10.4269/ajtmh.18-0922.
Using the 20-meter shuttle run test (20mSRT) as a morbidity metric, we assessed whether infection was associated with decreased aerobic capacity in Ugandan children across a range of altitudes, either at low (∼600 m) or high (∼1,000 m) altitudes. A total of 305 children were recruited from six schools within the Buliisa District, Lake Albert, Uganda. A subset ( = 96) of these had been previously assessed and treated for schistosomiasis ± malaria 2 weeks prior. Fitness scores on the 20mSRT were translated into VO2max using a standardized equation. Unadjusted and multivariable-adjusted analyses were performed using VO2max as the primary outcome. Analysis of fitness scores from 304 children, inclusive of the subset follow-up cohort, revealed a median VO2max of 45.4 mL kg min (interquartile range: 42.9-48.0 mL kg min). Children residing at high altitudes demonstrated increased aerobic capacities (46.3 versus 44.8 mL kg min, = 0.031). The prevalence of stunting, wasting, egg patent infection, malaria, giardiasis, anemia, and fecal occult blood were 36.7%, 16.1%, 44.3%, 65.2%, 21.4%, 50.6%, and 41.2%, respectively. Median VO2max was elevated in those previously treated, compared with those newly recruited (46.3 versus 44 mL kg min, < 0.001). Multivariable-adjusted analysis revealed a strong negative association between egg patent infection and VO2max at low altitude (beta coefficient: -3.96, 95% CI: -6.56 to -137, = 0.004). This is the first study to document a negative association between infection and aerobic capacity at low altitudes using the 20mSRT.
我们使用 20 米折返跑测试（20mSRT）作为发病率指标，评估了在乌干达不同海拔高度（低海拔约 600 米或高海拔约 1000 米）的儿童中，感染是否与有氧能力下降有关。共有 305 名儿童从乌干达艾伯特湖布利萨区的六所学校招募。其中一部分（=96 名）儿童在 2 周前曾接受过血吸虫病和疟疾的评估和治疗。使用标准化方程将 20mSRT 的体能得分转换为最大摄氧量（VO2max）。使用 VO2max 作为主要结局进行未调整和多变量调整分析。对包括亚组随访队列在内的 304 名儿童的体能得分进行分析，结果显示中位数 VO2max 为 45.4 mL·kg·min（四分位距：42.9-48.0 mL·kg·min）。生活在高海拔地区的儿童表现出更高的有氧能力（46.3 比 44.8 mL·kg·min，=0.031）。发育迟缓、消瘦、卵专利感染、疟疾、贾第虫病、贫血和粪便潜血的患病率分别为 36.7%、16.1%、44.3%、65.2%、21.4%、50.6%和 41.2%。与新招募的儿童相比，先前接受过治疗的儿童的中位数 VO2max 更高（46.3 比 44 mL·kg·min，<0.001）。多变量调整分析显示，低海拔地区卵专利感染与 VO2max 呈强烈负相关（β系数：-3.96，95%置信区间：-6.56 至-137，=0.004）。这是第一项使用 20mSRT 记录低海拔地区感染与有氧能力之间负相关的研究。
