蛙心室肌电缆特性分析。
An analysis of the cable properties of frog ventricular myocardium.
作者信息
Chapman R A, Fry C H
出版信息
J Physiol. 1978 Oct;283:263-82. doi: 10.1113/jphysiol.1978.sp012499.
Abstract
- The passive and active electrical parameters of frog ventricular myocardium have been measured. 2. The cytoplasmic resistivity has been determined by following changes in the resistance of a micro-electrode on penetration of a cell. 3. Unidimensional cable analysis using direct and alternating currents revealed the presence of a single time constant attributed to the surface membrane. 4. Longitudinal impedance measurements indicate that a second time constant is present in the intracellular pathway. 5. The results indicate that the resistance between cells is low so that action potentials can propagate from cell to cell by local circuits. 6. A three-dimensional cable analysis has also been carried out and compared to a simplified mathematical model which is presented in an Appendix and which closely approximates the experimental situation.
摘要
- 已测量青蛙心室肌的被动和主动电学参数。2. 通过跟踪微电极刺入细胞时电阻的变化来测定细胞质电阻率。3. 使用直流电和交流电的一维电缆分析揭示了归因于表面膜的单一时间常数的存在。4. 纵向阻抗测量表明细胞内通路中存在第二个时间常数。5. 结果表明细胞间电阻较低，因此动作电位可通过局部电路在细胞间传播。6. 还进行了三维电缆分析，并与附录中给出的、与实验情况非常接近的简化数学模型进行了比较。
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