Frick J, Aulitzky W
Urol Res. 1986;14(5):261-4. doi: 10.1007/BF00256570.
In this study we investigated the effect of low and high dosages of a potent LHRH agonist on the pituitary-gonadal axis with special consideration to the effect on the tubular compartment of the testis. Included were 3 treatment groups: the probands in Group I were treated with 3 X 50 micrograms HOE 766/week intranasally for 5 months; in Group II with 3 X 100 micrograms HOE 766 intranasally/day for 6 months and in Group III with 3 X 200 micrograms HOE 766 intranasally plus 5 mg fluoxymesterone orally/day for 5 months. With the low dose (Group I) no changes in the seminal parameters measured could be observed whereas LH and FSH levels increased in plasma, testosterone showed no change compared to pretreatment values. When high dosages/day of a potent LHRH agonist were administered without androgen replacement (Group II) pronounced decrease of LH and FSH took place, the testosterone plasma levels approached the female range. Spermatogenesis was arrested. The agonist plus androgen replacement (Group III) counteracted the suppression of spermatogenesis.
在本研究中，我们研究了低剂量和高剂量强效促黄体生成素释放激素（LHRH）激动剂对垂体-性腺轴的影响，并特别考虑了其对睾丸曲细精管的作用。研究包括3个治疗组：第一组的受试者每周经鼻给予3次，每次50微克HOE 766，持续5个月；第二组每天经鼻给予3次，每次100微克HOE 766，持续6个月；第三组每天经鼻给予3次，每次200微克HOE 766，并每天口服5毫克氟甲睾酮，持续5个月。低剂量组（第一组）未观察到所测精液参数有变化，而血浆中促黄体生成素（LH）和促卵泡生成素（FSH）水平升高，睾酮水平与治疗前相比无变化。当每天给予高剂量强效LHRH激动剂且未补充雄激素时（第二组），LH和FSH明显降低，血浆睾酮水平接近女性范围。精子发生停滞。激动剂加雄激素替代治疗组（第三组）抵消了对精子发生的抑制作用。
