School of Chemistry and Materials Science, Jiangsu Key Lab of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Xuzhou, Jiangsu 221116, P R China.
Org Biomol Chem. 2019 May 8;17(18):4564-4571. doi: 10.1039/c8ob03206h.
An N-heterocyclic carbene (NHC)-catalyzed α-functionalization of the in situ activated α,β-unsaturated carboxylic acids bearing γ-H was realized through formal [4 + 2] annulations with o-quinone methides, which paved a new avenue for the assembly and modification of the dihydrocoumarin scaffold in good yields with excellent diastereo- and enantioselectivities.
一种 N-杂环卡宾 (NHC)-催化的α-功能化反应，通过与邻醌甲醚的形式[4+2]环加成反应，实现了在原位活化的α,β-不饱和羧酸中γ-H 的反应，为二氢香豆素骨架的组装和修饰提供了一条新途径，具有良好的产率、优秀的非对映选择性和对映选择性。
