Gevú Kathlyn V, Carvalho Mário G DE, Silva Ilna G DA, Lima Helena R P, Castro Rosane N, Cunha Maura DA
Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Av. Alberto Lamego, 2000, Parque Califórnia, 28013-602 Campos dos Goytacazes, RJ, Brazil.
Instituto de Ciências Exatas, Departamento de Química, Universidade Federal Rural do Rio de Janeiro, BR 465, Km 07, s/n, 23897-000 Seropédica, RJ, Brazil.
An Acad Bras Cienc. 2019;91(1):e20180312. doi: 10.1590/0001-3765201920180312. Epub 2019 Apr 8.
This study aims to identify phenolic compounds in dichloromethane and methanolic extracts of the rhizome of Renealmia nicolaioides collected in the North Region of Brazil. Two known diarylheptanoids, 1,7-bis(4-hydroxyphenyl)-(1E)-1-hepten-3-one (1), and 5R-1,7-bis(4-hydroxyphenyl)-1E-hepten-5-ol (2), and a new one (1R,2S,5S)-2-hydroxy-1,7(p-hydroxyphenyl)-centrolobine (3), as well as one flavonoid, 3-metoxi-quercetin (4) were isolated by chromatographic procedure and identified by spectroscopic techniques (1H and13C NMR, HRMS and CD). The acetyl derivative of 2 was used to confirm its structure. All four compounds are reported for the first time for this genus, and this is the first occurrence of compound 1 as a natural metabolite. The results reported here are unprecedented for the genus Renealmia.
本研究旨在鉴定从巴西北部采集的尼古拉舞花姜根茎的二氯甲烷提取物和甲醇提取物中的酚类化合物。通过色谱法分离出两种已知的二芳基庚烷类化合物，1,7-双（4-羟基苯基）-（1E）-1-庚烯-3-酮（1）和5R-1,7-双（4-羟基苯基）-1E-庚烯-5-醇（2），以及一种新的化合物（1R,2S,5S）-2-羟基-1,7-（对羟基苯基）-中心洛宾（3），还有一种黄酮类化合物，3-甲氧基槲皮素（4），并通过光谱技术（1H和13C NMR、高分辨质谱和圆二色谱）对其进行鉴定。2的乙酰衍生物用于确认其结构。这四种化合物均首次在该属植物中被报道，化合物1作为天然代谢产物也是首次出现。本文报道的结果在舞花姜属中是前所未有的。
