Huang Huan, Zhu Zhengyan, Song Yu
Department of Gynecology, Tongren Hospital of Wuhan University (Wuhan Third Hospital), Wuhan City, Hubei Province, 430074, China.
Rev Assoc Med Bras (1992). 2019 Mar;65(3):336-341. doi: 10.1590/1806-9282.65.3.336. Epub 2019 Apr 11.
Ovarian endometriosis seriously affects the quality of life of females, and long non-coding RNA lncRNA urothelial carcinoma-associated 1 (UCA1) plays pivotal roles in the pathogenesis of various ovarian diseases. However, the involvement of lncRNA UCA1 in ovarian endometriosis remains unknown to date. Therefore, the present study aims to study the role of UCA1 in ovarian endometriosis.
A total of 98 patients with ovarian endometriosis and 28 healthy females were included. The expression of lncRNA UCA1 in ectopic and eutopic endometrium tissues of ovarian endometriosis patients and controls was detected using qRT-PCR. A ROC curve analysis was performed to evaluate the diagnostic values of serum lncRNA UCA1 for ovarian endometriosis. Patients were followed up for 2 years after discharge, and the recurrence of ovarian endometriosis was recorded.
The expression level of lncRNA UCA1 was significantly higher in ectopic endometrium tissues than in paired eutopic endometrium tissues for most of the patients. The serum lncRNA UCA1 level showed no significant correlations with either patients' age or living habits. After the treatment, the serum lncRNA UCA1 level increased, and serum levels of lncRNA UCA1 on the day of discharge were significantly lower in patients with recurrence than those in patients without recurrence. Conclusion: The downregulation of lncRNA UCA1 is involved in the pathogenesis of ovarian endometriosis and may serve as a promising diagnostic and prognostic biomarker for the disease.
卵巢子宫内膜异位症严重影响女性生活质量，长链非编码RNA尿路上皮癌相关1（UCA1）在多种卵巢疾病的发病机制中起关键作用。然而，lncRNA UCA1在卵巢子宫内膜异位症中的作用至今仍不清楚。因此，本研究旨在探讨UCA1在卵巢子宫内膜异位症中的作用。
共纳入98例卵巢子宫内膜异位症患者和28例健康女性。采用qRT-PCR检测卵巢子宫内膜异位症患者和对照组异位及在位子宫内膜组织中lncRNA UCA1的表达。进行ROC曲线分析以评估血清lncRNA UCA1对卵巢子宫内膜异位症的诊断价值。患者出院后随访2年，记录卵巢子宫内膜异位症的复发情况。
大多数患者异位子宫内膜组织中lncRNA UCA1的表达水平显著高于配对的在位子宫内膜组织。血清lncRNA UCA1水平与患者年龄和生活习惯均无显著相关性。治疗后，血清lncRNA UCA1水平升高，复发患者出院当天血清lncRNA UCA1水平显著低于未复发患者。结论：lncRNA UCA1的下调参与卵巢子宫内膜异位症的发病机制，可能是该疾病有前景的诊断和预后生物标志物。
