Gonzenbach R, Satz N, Vetter W, Jenni R, Krayenbühl H P
Schweiz Med Wochenschr. 1978 Nov 4;108(44):1710-2.
In 14 patients with essential hypertension, left ventricular function was assessed echocardiographically before and after 4 and 8 weeks of treatment with the betablocking agent atenolol. Atenolol was given orally in a dose of 100 mg/day. After 4 weeks of treatment systolic blood pressure decreased from 160 to 138 mm Hg(p less than 0.001) and diastolic pressure from 105 to 91 mm Hg(p less than 0.001). Heart rate decreased from 76 to 64 beats/min (p less than 0.05). Systolic shortening of the left ventricular transverse diameter declined from 41 to 36% (p less than 0.01), though in no instance did it fall below the lower limit of normality (30%). After 8 weeks of betablocking therapy, blood pressure and heart rate remained essentially unchanged. Systolic shortening increased slightly but insignificantly to 38%. The left ventricular enddiastolic diameter did not change throughout the study. It is concluded that longterm betablocking therapy is associated with a significant reduction of left ventricular function which improves in the later stage of treatment. Since the diminution of left ventricular function is slight, the induction of left heart decompensation is unlikely, at any rate in patients with initially normal left ventricular function.
对14例原发性高血压患者，在使用β受体阻滞剂阿替洛尔治疗4周和8周前后，采用超声心动图评估左心室功能。阿替洛尔口服剂量为100mg/天。治疗4周后，收缩压从160mmHg降至138mmHg（p<0.001），舒张压从105mmHg降至91mmHg（p<0.001）。心率从76次/分钟降至64次/分钟（p<0.05）。左心室横径的收缩期缩短率从41%降至36%（p<0.01），但在任何情况下均未降至正常下限（30%）以下。β受体阻滞剂治疗8周后，血压和心率基本保持不变。收缩期缩短率略有增加，但不显著，增至38%。在整个研究过程中，左心室舒张末期直径未发生变化。结论是，长期β受体阻滞剂治疗与左心室功能显著降低有关，而在治疗后期左心室功能有所改善。由于左心室功能的降低轻微，因此至少在初始左心室功能正常的患者中，不太可能诱发左心代偿失调。
