创伤后应激障碍的德国武装部队人员睡眠结构的变化与抑郁和健康对照组比较。
Changes in sleep architecture in German Armed Forces personnel with posttraumatic stress disorder compared with depressed and healthy control subjects.
机构信息
German Armed Forces Hospital Hamburg, Centre for Mental Health, Hamburg, Germany.
University Medical Centre Hamburg-Eppendorf, Department of Medical Psychology, Hamburg, Germany.
出版信息
PLoS One. 2019 Apr 17;14(4):e0215355. doi: 10.1371/journal.pone.0215355. eCollection 2019.
BACKGROUND
This study compares the sleep architecture of patients with posttraumatic stress disorder (PTSD) with that of both patients with depression and subjects with no mental disorder.
METHOD
45 German armed forces personnel with PTSD, 72 German armed forces personnel with depression and 24 healthy control subjects underwent 24-hour polysomnography. The effects of group membership, medication and the statistical interaction of group and medication were analysed for the following variables: sleep onset latency, REM sleep latency, slow-wave sleep and REM sleep percentages.
RESULTS
Sleep onset latency was significantly prolonged in both the PTSD and the depression group. Moreover, psychotropic medication was associated with significantly prolonged REM sleep latency.
CONCLUSION
The impact on sleep onset latency is of special clinical relevance in that according to preliminary studies, it is of major importance for subjective sleep quality. In contrast to the other parameters, an increase in sleep onset latency results in a subjective reduction in sleep quality which can lead to hyperarousal and increased preoccupation with sleep, which in turn may lead to dysfunctional sleep patterns.
背景
本研究比较了创伤后应激障碍（PTSD）患者、抑郁症患者和无精神障碍患者的睡眠结构。
方法
45 名德国武装部队 PTSD 患者、72 名德国武装部队抑郁症患者和 24 名健康对照者接受了 24 小时多导睡眠图检查。分析了组别的影响、药物的影响以及组与药物的统计交互作用对以下变量的影响：睡眠潜伏期、快速眼动睡眠潜伏期、慢波睡眠和快速眼动睡眠百分比。
结果
PTSD 组和抑郁症组的睡眠潜伏期均显著延长。此外，精神药物治疗与 REM 睡眠潜伏期显著延长相关。
结论
睡眠潜伏期的影响具有特殊的临床意义，因为根据初步研究，它对主观睡眠质量具有重要意义。与其他参数不同，睡眠潜伏期的增加会导致主观睡眠质量下降，从而导致过度警觉和对睡眠的过度关注，进而导致睡眠模式失调。
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