Abe F, Shibuya H, Tateyama M, Ommura Y, Azumi N, Kimura K
Acta Pathol Jpn. 1986 Oct;36(10):1507-12. doi: 10.1111/j.1440-1827.1986.tb02822.x.
Increased susceptibility to Rhizopus oryzae in diabetes was investigated using mice in which diabetic ketoacidosis was experimentally induced. All of the diabetic mice which had developed ketoacidosis died within four days after inoculation of R. oryzae and their serum UIBCs (Unbound iron binding capacity) were significantly lower than those of the normal control mice. This study suggested that the decreased serum UIBC produced by diabetic ketoacidosis enhances the growth of R. oryzae in vivo.
利用实验性诱导糖尿病酮症酸中毒的小鼠，研究了糖尿病患者对米根霉易感性增加的情况。所有发生酮症酸中毒的糖尿病小鼠在接种米根霉后四天内死亡，其血清未结合铁结合能力（UIBC）显著低于正常对照小鼠。本研究表明，糖尿病酮症酸中毒导致的血清UIBC降低会促进米根霉在体内的生长。
