Waldorf A R, Diamond R D
Infect Immun. 1984 Apr;44(1):194-5. doi: 10.1128/iai.44.1.194-195.1984.
Rhinocerebral involvement is the most common form of mucormycosis in uncontrolled diabetic patients. Streptozotocin-induced diabetic and normal mice were challenged by intrasinus inoculation of Rhizopus oryzae to determine their susceptibility to infection by this route. Ninety percent of diabetic mice and no normal mice died after inoculation with 10(6) spores. Intrasinus inoculations caused minimal direct trauma and low levels of brain inocula, but progressive cerebral infections were induced in diabetic mice.
鼻脑受累是未控制的糖尿病患者中毛霉菌病最常见的形式。通过鼻窦内接种米根霉对链脲佐菌素诱导的糖尿病小鼠和正常小鼠进行攻击，以确定它们经此途径感染的易感性。接种10(6)个孢子后，90%的糖尿病小鼠死亡，而正常小鼠无一死亡。鼻窦内接种造成的直接创伤极小，脑内接种量低，但糖尿病小鼠仍引发了进行性脑感染。
