泰国新生儿重症监护病房中耐抗菌革兰氏阴性菌定植的婴儿。
Antimicrobial-resistant Gram-negative colonization in infants from a neonatal intensive care unit in Thailand.
机构信息
Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao Democratic People's Republic.
Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
出版信息
J Hosp Infect. 2019 Oct;103(2):151-155. doi: 10.1016/j.jhin.2019.04.004. Epub 2019 Apr 14.
Antimicrobial-resistant Gram-negative bacteria are a major cause of morbidity and mortality in hospitalized neonates in South and South-East Asia. This study aimed to determine the dynamics of colonization with antimicrobial-resistant Gram-negative bacteria amongst patients in a neonatal intensive care unit (NICU) in Thailand. From 97 enrolled patients, 52% were colonized by an extended-spectrum β-lactamase (ESBL) organism at some point during their stay and 64% were colonized by a carbapenem-resistant organism. Rapid acquisition of ESBL-positive and carbapenem-resistant organisms was found. Once colonized with an antibiotic-resistant organism, patients remained colonized for the remainder of their NICU stay.
在南亚和东南亚，耐抗生素革兰氏阴性菌是导致住院新生儿发病和死亡的主要原因。本研究旨在确定泰国新生儿重症监护病房（NICU）患者中耐抗生素革兰氏阴性菌定植的动态变化。在 97 名入组患者中，52%的患者在住院期间的某个时间点被产超广谱β-内酰胺酶（ESBL）的生物体定植，64%的患者被碳青霉烯类耐药的生物体定植。发现 ESBL 阳性和碳青霉烯类耐药生物体的快速获得。一旦定植了抗生素耐药的生物体，患者在整个 NICU 住院期间都会持续定植。
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