转化生长因子-β 信号在免疫和癌症中的作用。
Transforming Growth Factor-β Signaling in Immunity and Cancer.
机构信息
Institute for Research in Biomedicine (IRB Barcelona), the Barcelona Institute of Science and Technology, Baldiri Reixac 10, 08028 Barcelona, Spain; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Barcelona, Spain; ICREA, Passeig Lluís Companys 23, 08010 Barcelona, Spain.
Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
出版信息
Immunity. 2019 Apr 16;50(4):924-940. doi: 10.1016/j.immuni.2019.03.024.
Abstract
Transforming growth factor (TGF)-β is a crucial enforcer of immune homeostasis and tolerance, inhibiting the expansion and function of many components of the immune system. Perturbations in TGF-β signaling underlie inflammatory diseases and promote tumor emergence. TGF-β is also central to immune suppression within the tumor microenvironment, and recent studies have revealed roles in tumor immune evasion and poor responses to cancer immunotherapy. Here, we present an overview of the complex biology of the TGF-β family and its context-dependent nature. Then, focusing on cancer, we discuss the roles of TGF-β signaling in distinct immune cell types and how this knowledge is being leveraged to unleash the immune system against the tumor.
摘要
转化生长因子 (TGF)-β 是免疫稳态和耐受的关键执行者，抑制免疫系统的许多成分的扩张和功能。TGF-β 信号的紊乱是炎症性疾病的基础，并促进肿瘤的发生。TGF-β 在肿瘤微环境中的免疫抑制中也很重要，最近的研究揭示了它在肿瘤免疫逃逸和对癌症免疫治疗反应不佳中的作用。在这里，我们概述了 TGF-β 家族的复杂生物学及其与上下文相关的性质。然后，我们专注于癌症，讨论 TGF-β 信号在不同免疫细胞类型中的作用，以及如何利用这些知识来释放免疫系统对抗肿瘤。
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