2'-甲氧基苯乙酮作为 DNA 光引发剂的瞬态紫外可见吸收光谱特性。
Transient UV-vis absorption spectroscopic characterisation of 2'-methoxyacetophenone as a DNA photosensitiser.
机构信息
Instituto Universitario Mixto de Tecnología Química, Universitat Politècnica de València (UPV-CSIC), Av. Los Naranjos s/n, 46022, Valencia, Spain.
出版信息
Spectrochim Acta A Mol Biomol Spectrosc. 2019 Jul 5;218:191-195. doi: 10.1016/j.saa.2019.04.007. Epub 2019 Apr 6.
2'-Methoxyacetophenone (2M) presents improved UVA absorption as compared with other acetophenone derivatives. On the basis of transient infrared spectroscopy it has been previously claimed that 2M is an interesting photosensitiser for cyclobutane pyrimidine dimers (CPDs) formation. In the present paper, a complete UV-Vis transient absorption spectroscopic characterisation of this compound is provided, including triplet-triplet spectra, triplet lifetimes and rate constants for quenching of 2M by a dimeric thymine derivative. Furthermore, generation of singlet oxygen has been proven by time-resolved near IR phosphorescence measurements. Overall, the obtained results confirm the potential of 2M as a DNA photosensitiser, not only for CPDs formation, but also for oxidative damage.
2'-甲氧基苯乙酮（2M）与其他苯乙酮衍生物相比，具有更好的 UVA 吸收能力。基于瞬态红外光谱，先前有研究声称 2M 是一种有趣的环丁烷嘧啶二聚体（CPD）形成的光增敏剂。在本文中，提供了对该化合物的完整紫外可见瞬态吸收光谱特性的描述，包括三重态-三重态光谱、三重态寿命以及二聚体胸腺嘧啶衍生物对 2M 的猝灭速率常数。此外，通过时间分辨近红外磷光测量证明了单线态氧的生成。总的来说，所获得的结果证实了 2M 作为 DNA 光增敏剂的潜力，不仅可用于 CPDs 的形成，还可用于氧化损伤。
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