Rarey K E, Bicknell J M, Davis L E
Am J Otolaryngol. 1986 Nov-Dec;7(6):387-90. doi: 10.1016/s0196-0709(86)80012-6.
Temporal bones from a 64-year-old man who had Cogan's syndrome were examined by light microscopy. Although tissues of the middle ear appeared unremarkable, extensive ectopic bone formation was observed bilaterally in the inner ear membranous labyrinth. Such osteogenesis completely obliterated the cochlear compartments apically. Only the scala tympani compartment of the basal cochlear turn remained patent. Ectopic bone tissue was observed also in the vestibular semicircular canals. Marked degeneration of eighth nerve fibers and associated ganglion cells also was observed. To our knowledge, this report represents only the fourth temporal bone findings of Cogan's syndrome and demonstrates a more advanced pathologic state of inner ear pathology than those reported previously.
对一名患有科根综合征的64岁男性的颞骨进行了光学显微镜检查。尽管中耳组织看起来无异常，但在内耳膜迷路双侧观察到广泛的异位骨形成。这种骨生成完全闭塞了耳蜗顶部的腔室。仅基底耳蜗转的鼓阶腔室保持通畅。在前庭半规管中也观察到了异位骨组织。还观察到了第八神经纤维和相关神经节细胞的明显退化。据我们所知，本报告仅代表科根综合征的第四例颞骨检查结果，并且显示出比先前报告的内耳病理状态更严重。
