Bravin Carlo, Guidetti Andrea, Licini Giulia, Zonta Cristiano
Department of Chemical Sciences , University of Padova , Via Marzolo 1 , 35131 Padova , Italy . Email:
Chem Sci. 2019 Feb 6;10(12):3523-3528. doi: 10.1039/c8sc05527k. eCollection 2019 Mar 28.
Dynamic covalent libraries (DCLs) have been widely used in the development of differential sensors. Inspired by recent studies which use supramolecular recognition systems for sensing, we report the use of a tris(-pyridylmethyl)amine (TPMA)-based supramolecular cage as a differential sensor for dicarboxylate anions. In particular, a library of molecular cages constituted by linkers differing in size and flexibility was allowed to equilibrate toward a series of guests differing in molecular size. The differential system was able to discriminate a series of dicarboxylates depending on their chain length. This differentiation was evaluated through the application of the Principal Component Analysis (PCA) method using interpolated and raw data obtained from ESI-MS. Interestingly, while the H NMR spectra of the differential system did not allow for the discrimination of the analytes by the naked eye, PCA of the raw data from the spectra revealed information on the chain length of the guest and also on the odd-even character of the carbon chain.
动态共价库（DCLs）已广泛应用于差分传感器的开发。受近期使用超分子识别系统进行传感的研究启发，我们报道了使用基于三（吡啶甲基）胺（TPMA）的超分子笼作为二羧酸根阴离子的差分传感器。具体而言，由大小和灵活性不同的连接体构成的分子笼库被允许朝着一系列分子大小不同的客体达到平衡。该差分系统能够根据二羧酸根的链长区分一系列二羧酸根。通过应用主成分分析（PCA）方法，使用从电喷雾电离质谱（ESI-MS）获得的内插数据和原始数据对这种区分进行了评估。有趣的是，虽然差分系统的核磁共振氢谱（H NMR）不允许肉眼区分分析物，但光谱原始数据的PCA揭示了有关客体链长以及碳链奇偶性的信息。
Zotero 插件
