[苄硝唑治疗恰加斯病诱发的周围性多发性神经病]

[Peripheral polyneuropathy induced by benzonidazole in the treatment of Chagas' disease].

作者信息

Defaria C R, De Melo-Souza S E, Rassi A

出版信息

Arq Neuropsiquiatr. 1986 Jun;44(2):125-9. doi: 10.1590/s0004-282x1986000200003.

DOI:10.1590/s0004-282x1986000200003

Abstract

Neurophysiological examination before and after the administration of benzonidazole, has shown peripheral polyneuropathy induced by this drug in most of the patients treated for chronic Chagas' disease. The polyneuropathy was mostly axonal and it was dose dependent being more severe in patients who had denervation of skeletal muscles before receiving the drug.

摘要

在给予苄硝唑前后进行的神经生理学检查表明，在大多数接受慢性恰加斯病治疗的患者中，该药物会诱发周围性多发性神经病。这种多发性神经病主要是轴索性的，且呈剂量依赖性，在接受药物治疗前已有骨骼肌去神经支配的患者中更为严重。