苯硝唑治疗成人恰加斯病的耐受性。
Tolerance of benznidazole in treatment of Chagas' disease in adults.
机构信息
Tropical Diseases Section, Barcelona Centre for International Health Research, Hospital Clinic, Villarroel 170, Barcelona, Spain.
出版信息
Antimicrob Agents Chemother. 2010 Nov;54(11):4896-9. doi: 10.1128/AAC.00537-10. Epub 2010 Sep 7.
Abstract
Chagas' disease is an emerging public health problem in areas where the disease is not endemic. Treatment with benznidazole has shown efficacy in the acute stage of the disease, but its efficacy in the chronic stage remains controversial, and unwanted side effects are more frequent and severe in adults than in children. This study describes the profile of side effects of benznidazole in a cohort of Trypanosoma cruzi-infected patients in a European country.
摘要
恰加斯病在非流行地区是一个新出现的公共卫生问题。贝那唑嗪治疗在疾病的急性期显示出疗效，但在慢性期的疗效仍存在争议，且成年人比儿童更常出现且更严重的不良反应。本研究描述了在一个欧洲国家的克氏锥虫感染患者队列中贝那唑嗪的不良反应特征。
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