Children's Hospital, Zhejiang University School of Medicine, Hangzhou, 310052, China.
Department of Clinical Medicine, Zhejiang University City College, Hangzhou, 310015, China.
World J Pediatr. 2019 Oct;15(5):415-421. doi: 10.1007/s12519-019-00253-3. Epub 2019 Apr 17.
Formation of protein complexes across synapses is a critical process in neurodevelopment, having direct implications on brain function and animal behavior. Here, we present the understanding, importance, and potential impact of a newly found regulator of such a key interaction.
A systematic search of the literature was conducted on PubMed (Medline), Embase, and Central-Cochrane Database.
Membrane-associated mucin domain-containing glycosylphosphatidylinositol anchor proteins (MDGAs) were recently discovered to regulate synaptic development and transmission via suppression of neurexins-neuroligins trans-synaptic complex formation. MDGAs also regulate axonal migration and outgrowth. In the context of their physiological role, we begin to consider the potential links to the etiology of certain neurodevelopmental disorders. We present the gene expression and protein structure of MDGAs and discuss recent progress in our understanding of the neurobiological role of MDGAs to explore its potential as a therapeutic target.
MDGAs play a key role in neuron migration, axon guidance and synapse development, as well as in regulating brain excitation and inhibition balance.
突触间蛋白质复合物的形成是神经发育的关键过程，直接影响大脑功能和动物行为。在这里，我们介绍了一种新发现的关键相互作用调节剂的理解、重要性和潜在影响。
在 PubMed（Medline）、Embase 和中央 Cochrane 数据库中进行了系统的文献检索。
最近发现，膜相关粘蛋白结构域富含糖磷脂酰肌醇锚蛋白（MDGAs）通过抑制神经连接蛋白-神经递质结合蛋白跨突触复合物的形成来调节突触的发育和传递。MDGAs 还调节轴突迁移和生长。在其生理作用的背景下，我们开始考虑与某些神经发育障碍病因的潜在联系。我们介绍了 MDGAs 的基因表达和蛋白质结构，并讨论了我们对 MDGAs 的神经生物学作用的理解的最新进展，以探索其作为治疗靶点的潜力。
MDGAs 在神经元迁移、轴突导向和突触发育以及调节大脑兴奋和抑制平衡方面发挥着关键作用。
