RW-2018 研究研讨会：营养对表观遗传状态、生长和健康的影响。
RW-2018-Research Workshop: The Effect of Nutrition on Epigenetic Status, Growth, and Health.
机构信息
Center for Reproductive Biology School of Biological Sciences, Washington State University, Pullman, Washington, USA.
Department of Epidemiology Mailman School of Public Health, Columbia University Medical Center, New York, New York, USA.
出版信息
JPEN J Parenter Enteral Nutr. 2019 Jul;43(5):627-637. doi: 10.1002/jpen.1536. Epub 2019 Apr 17.
The goal of the 2018 American Society for Parenteral and Enteral Nutrition (ASPEN) Research Workshop was to explore the influence of nutrition and dietary exposure to xenobiotics on the epigenome during critical periods in development and how these exposures influence both disease incidence and severity transgenerationally. A growing compendium of research indicates that the incidence and severity of common and costly human diseases may be influenced by dietary exposures and deficiencies that modify the epigenome. The greatest periods of vulnerability to these exposures are the periconception period and early childhood. Xenobiotics in the food chain, protein malnutrition, and methyl donor deficiencies could have a profound bearing on the risk of developing heart disease, diabetes, obesity, hypertension, and mental illness over multiple generations. The financial impact and the life burden of these diseases are enormous. These and other aspects of nutrition, epigenetics, and health are explored in this research workshop.
2018 年美国肠外与肠内营养学会（ASPEN）研究研讨会的目标是探索营养和膳食中外源化学物质对发育关键期表观基因组的影响，以及这些暴露如何在代际间影响疾病的发病率和严重程度。越来越多的研究表明，常见和昂贵的人类疾病的发病率和严重程度可能受到改变表观基因组的饮食暴露和缺乏的影响。最容易受到这些暴露影响的时期是围孕期和儿童早期。食物链中的外源化学物质、蛋白质营养不良和甲基供体缺乏，可能会对多代人患心脏病、糖尿病、肥胖症、高血压和精神疾病的风险产生深远影响。这些疾病的经济影响和生活负担是巨大的。本研究研讨会探讨了营养、表观遗传学和健康的这些方面。
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