Aronica Lucia, Levine A Joan, Brennan Kevin, Mi Jeffrey, Gardner Christopher, Haile Robert W, Hitchins Megan P
Division of Oncology, Department of Medicine, Stanford University, Stanford, CA 94305, USA.
Department of Medicine, Stanford Prevention Research Center, Stanford University, Stanford, CA 94305, USA.
Epigenomics. 2017 May;9(5):769-787. doi: 10.2217/epi-2016-0182.
Obesity results from the interaction of genetic and environmental factors, which may involve epigenetic mechanisms such as DNA methylation (DNAm).
MATERIALS & METHODS: We have followed the PRISMA protocol to select studies that analyzed DNAm at baseline and end point of a weight loss intervention using either candidate-locus or genome-wide approaches.
Six genes displayed weight loss associated DNAm across four out of nine genome-wide studies. Weight loss is associated with significant but small changes in DNAm across the genome, and weight loss outcome is associated with individual differences in baseline DNAm at several genomic locations.
The identified weight loss associated DNAm markers, especially those showing reproducibility across different studies, warrant validation by further studies with robust design and adequate power.
肥胖是由遗传和环境因素相互作用导致的，这可能涉及DNA甲基化（DNAm）等表观遗传机制。
我们遵循PRISMA方案来选择研究，这些研究使用候选基因位点或全基因组方法分析减肥干预基线和终点时的DNAm。
在九项全基因组研究中的四项研究里，六个基因显示出与减肥相关的DNAm。减肥与全基因组DNAm的显著但微小的变化相关，并且减肥结果与几个基因组位置的基线DNAm个体差异相关。
所确定的与减肥相关的DNAm标记，尤其是那些在不同研究中具有可重复性的标记，需要通过设计合理且有足够效力的进一步研究来验证。
