MTHFD1 在肝细胞癌中的过表达预示着更差的生存和复发情况。
Overexpression of MTHFD1 in hepatocellular carcinoma predicts poorer survival and recurrence.
机构信息
Department of Pathology, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, 200438, PR China.
Key Laboratory of Signaling Regulation & Targeting Therapy of Liver Cancer, The Second Military Medical University, Ministry of Education, Shanghai, 200438, PR China.
出版信息
Future Oncol. 2019 May;15(15):1771-1780. doi: 10.2217/fon-2018-0606. Epub 2019 Apr 18.
MTHFD1 was the enzyme providing one-carbon derivatives of tetrahydrofolate. We sought to investigate the impact of MTHFD1 on hepatocellular carcinoma (HCC). Bioinformatic analysis, western blot and immunohistochemistry were conducted to detect MTHFD1 expression in HCC. The relationships between MTHFD1 and prognosis of 172 HCCs were analyzed by Kaplan-Meier method and Cox proportional hazards model. High MTHFD1 expression in HCC represented poor prognosis (overall survival p = 0.025; time to recurrence p = 0.044). Combining MTHFD1 with serum AFP, survival analysis demonstrated the prognosis of the MTHFD1 low expression and AFP ≤20 ng/ml group was better than that of the MTHFD1 high expression or AFP >20 ng/ml group and the MTHFD1 high expression and AFP >20 ng/ml group (overall survival p < 0.0001; time to recurrence p < 0.0001). High MTHFD1 expression in HCC indicated poorer prognosis. Combining MTHFD1 with serum AFP improved the accuracy of prognostic prediction.
MTHFD1 是提供四氢叶酸一碳衍生物的酶。我们试图研究 MTHFD1 对肝细胞癌（HCC）的影响。通过生物信息学分析、western blot 和免疫组织化学检测 HCC 中 MTHFD1 的表达。通过 Kaplan-Meier 方法和 Cox 比例风险模型分析 172 例 HCC 中 MTHFD1 与预后的关系。HCC 中高 MTHFD1 表达预示预后不良（总生存 p = 0.025；复发时间 p = 0.044）。将 MTHFD1 与血清 AFP 相结合，生存分析表明 MTHFD1 低表达和 AFP ≤20ng/ml 组的预后优于 MTHFD1 高表达或 AFP >20ng/ml 组和 MTHFD1 高表达和 AFP >20ng/ml 组（总生存 p < 0.0001；复发时间 p < 0.0001）。HCC 中高 MTHFD1 表达预示预后不良。将 MTHFD1 与血清 AFP 相结合可提高预后预测的准确性。
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