Specific association of expressions with small cell lung cancer development and chemoradiotherapy outcome.

OBJECTIVES

To identify biomarkers that can discriminated small cell lung cancer (SCLC) from non-SCLC (NSCLC), and explore their association with the prognosis of SCLC under chemoradiotherapy.

METHODS

The GSE40275 dataset was used to identify potential targets in SCLC. There were 196 patients of lung cancer (LC) in cohort 1 of this study. levels in tissues were determined by immunohistochemistry assay in cohort 1. Lung cancer patients who were all underwent local chemoradiotherapy (CRT) were included in cohort 2, and the association of levels with CRT treatment outcome were determined in cohort 2. Cell experiments were used to determine the function of on the radio-sensitivity of SCLC and NSCLC cells.

RESULTS

The levels in LC tissues were increased, and could discriminate SCLC from both lung squamous cell carcinoma (LUSC) and lung adenocarcinoma (LUAD). Small cell lung cancer patients with high phenotype had a poorer prognosis after CRT treatment, whereas no significant correlation was found between levels and prognosis in LUSC and LUAD group. Cell experiments demonstrated that overexpression of increases radio-resistance in both SCLC and NSCLC in vitro.

CONCLUSION

expressions might be a novel specifically prognostic biomarker for SCLC and the CRT treatment outcome.