可溶性 TREM2 与神经退行性疾病中中枢和外周炎症的生物标志物。
Soluble TREM2 and biomarkers of central and peripheral inflammation in neurodegenerative disease.
机构信息
Cleveland Clinic, Genomic Medicine Institute, Cleveland, OH, United States.
Cleveland Clinic, Genomic Medicine Institute, Cleveland, OH, United States.
出版信息
J Neuroimmunol. 2018 Jun 15;319:19-27. doi: 10.1016/j.jneuroim.2018.03.003. Epub 2018 Mar 20.
Abstract
Alzheimer's disease (AD) has been genetically and pathologically associated with neuroinflammation. Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial receptor involved in innate immunity. TREM2 rare protein coding genetic variants have been linked to AD. A soluble TREM2 (sTREM2) cleavage product is elevated in AD. It is unclear whether there is a relationship between elevated sTREM2 and markers of inflammation. The hypothesis of this investigation was that central and peripheral inflammation play a role in sTREM2 levels in AD. A consistent association of peripheral or central markers of inflammation and CSF sTREM2 levels was not found, suggesting a limited impact of general inflammation on sTREM2 levels. An association between peripheral sTREM2 levels and CSF sTREM2, as well as an association between CSF sTREM2 and a marker of blood brain barrier integrity, was observed in AD, suggesting a potential role of peripheral TREM2 in central TREM2 biology.
摘要
阿尔茨海默病（AD）在遗传和病理学上与神经炎症有关。髓样细胞触发受体 2（TREM2）是一种参与固有免疫的小胶质细胞受体。TREM2 罕见的蛋白编码基因突变与 AD 有关。可溶性 TREM2（sTREM2）裂解产物在 AD 中升高。目前尚不清楚升高的 sTREM2 是否与炎症标志物有关。本研究的假设是中枢和外周炎症在 AD 中的 sTREM2 水平中起作用。外周或中枢炎症标志物与 CSF sTREM2 水平之间没有一致的关联，这表明一般炎症对 sTREM2 水平的影响有限。在 AD 中观察到外周 sTREM2 水平与 CSF sTREM2 之间以及 CSF sTREM2 与血脑屏障完整性标志物之间的关联，这表明外周 TREM2 可能在中枢 TREM2 生物学中发挥作用。
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