• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

可溶性 TREM2 与神经退行性疾病中中枢和外周炎症的生物标志物。

Soluble TREM2 and biomarkers of central and peripheral inflammation in neurodegenerative disease.

机构信息

Cleveland Clinic, Genomic Medicine Institute, Cleveland, OH, United States.

Cleveland Clinic, Genomic Medicine Institute, Cleveland, OH, United States.

出版信息

J Neuroimmunol. 2018 Jun 15;319:19-27. doi: 10.1016/j.jneuroim.2018.03.003. Epub 2018 Mar 20.

DOI:10.1016/j.jneuroim.2018.03.003
PMID:29685286
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6036902/
Abstract

Alzheimer's disease (AD) has been genetically and pathologically associated with neuroinflammation. Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial receptor involved in innate immunity. TREM2 rare protein coding genetic variants have been linked to AD. A soluble TREM2 (sTREM2) cleavage product is elevated in AD. It is unclear whether there is a relationship between elevated sTREM2 and markers of inflammation. The hypothesis of this investigation was that central and peripheral inflammation play a role in sTREM2 levels in AD. A consistent association of peripheral or central markers of inflammation and CSF sTREM2 levels was not found, suggesting a limited impact of general inflammation on sTREM2 levels. An association between peripheral sTREM2 levels and CSF sTREM2, as well as an association between CSF sTREM2 and a marker of blood brain barrier integrity, was observed in AD, suggesting a potential role of peripheral TREM2 in central TREM2 biology.

摘要

阿尔茨海默病（AD）在遗传和病理学上与神经炎症有关。髓样细胞触发受体 2（TREM2）是一种参与固有免疫的小胶质细胞受体。TREM2 罕见的蛋白编码基因突变与 AD 有关。可溶性 TREM2（sTREM2）裂解产物在 AD 中升高。目前尚不清楚升高的 sTREM2 是否与炎症标志物有关。本研究的假设是中枢和外周炎症在 AD 中的 sTREM2 水平中起作用。外周或中枢炎症标志物与 CSF sTREM2 水平之间没有一致的关联，这表明一般炎症对 sTREM2 水平的影响有限。在 AD 中观察到外周 sTREM2 水平与 CSF sTREM2 之间以及 CSF sTREM2 与血脑屏障完整性标志物之间的关联，这表明外周 TREM2 可能在中枢 TREM2 生物学中发挥作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9824/6036902/c59ad4df2ff8/nihms955022f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9824/6036902/d56f6c49e94d/nihms955022f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9824/6036902/7ce2aab455f6/nihms955022f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9824/6036902/d60c00dab008/nihms955022f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9824/6036902/c308dac9cece/nihms955022f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9824/6036902/37b32fba37c9/nihms955022f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9824/6036902/8ceef27f8097/nihms955022f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9824/6036902/c59ad4df2ff8/nihms955022f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9824/6036902/d56f6c49e94d/nihms955022f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9824/6036902/7ce2aab455f6/nihms955022f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9824/6036902/d60c00dab008/nihms955022f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9824/6036902/c308dac9cece/nihms955022f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9824/6036902/37b32fba37c9/nihms955022f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9824/6036902/8ceef27f8097/nihms955022f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9824/6036902/c59ad4df2ff8/nihms955022f7.jpg

相似文献

1
Soluble TREM2 and biomarkers of central and peripheral inflammation in neurodegenerative disease.可溶性 TREM2 与神经退行性疾病中中枢和外周炎症的生物标志物。
J Neuroimmunol. 2018 Jun 15;319:19-27. doi: 10.1016/j.jneuroim.2018.03.003. Epub 2018 Mar 20.
2
Variants in the MS4A cluster interact with soluble TREM2 expression on biomarkers of neuropathology.MS4A 簇中的变异与可溶性 TREM2 表达相互作用，影响神经病理学生物标志物。
Mol Neurodegener. 2024 May 18;19(1):41. doi: 10.1186/s13024-024-00727-7.
3
Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer's disease.阿尔茨海默病患者脑脊液中可溶性触发受体表达分子2（TREM2）浓度升高。
Mol Neurodegener. 2016 Jan 12;11:3. doi: 10.1186/s13024-016-0071-x.
4
Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status.脑脊液可溶性触发受体表达分子2（TREM2）在阿尔茨海默病中水平较高，且与突变状态相关。
Acta Neuropathol. 2016 Jun;131(6):925-33. doi: 10.1007/s00401-016-1533-5. Epub 2016 Jan 11.
5
Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology.阿尔茨海默病患者脑脊液 sTREM2 的早期增加与 tau 相关的神经退行性变有关，但与淀粉样蛋白-β 病理学无关。
Mol Neurodegener. 2019 Jan 10;14(1):1. doi: 10.1186/s13024-018-0301-5.
6
TREM2 expression in the brain and biological fluids in prion diseases.朊病毒病中脑组织和生物体液中的 TREM2 表达。
Acta Neuropathol. 2021 Jun;141(6):841-859. doi: 10.1007/s00401-021-02296-1. Epub 2021 Apr 21.
7
Plasma levels of soluble TREM2 and neurofilament light chain in TREM2 rare variant carriers.TREM2 罕见变异携带者的可溶性 TREM2 和神经丝轻链的血浆水平。
Alzheimers Res Ther. 2019 Nov 28;11(1):94. doi: 10.1186/s13195-019-0545-5.
8
Dynamic changes of CSF sTREM2 in preclinical Alzheimer's disease: the CABLE study.临床前阿尔茨海默病患者脑脊液 sTREM2 的动态变化：CABLE 研究。
Mol Neurodegener. 2020 Apr 10;15(1):25. doi: 10.1186/s13024-020-00374-8.
9
Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model.可溶性 TREM2 通过调节阿尔茨海默病模型中小胶质细胞的功能来改善病理表型。
Nat Commun. 2019 Mar 25;10(1):1365. doi: 10.1038/s41467-019-09118-9.
10
Soluble TREM2 changes during the clinical course of Alzheimer's disease: A meta-analysis.可溶性触发受体表达分子2（TREM2）在阿尔茨海默病临床病程中的变化：一项荟萃分析。
Neurosci Lett. 2018 Nov 1;686:10-16. doi: 10.1016/j.neulet.2018.08.038. Epub 2018 Aug 29.

引用本文的文献

1
Image-Derived Blood Normalization of Antibody-Based TREM2 PET in Mouse Models of Amyloidosis and Myocardial Infarction.淀粉样变性和心肌梗死小鼠模型中基于抗体的TREM2 PET的图像衍生血液归一化
J Nucl Med. 2025 Sep 2;66(9):1419-1424. doi: 10.2967/jnumed.125.269472.
2
Effect of neuroinflammation on the progression of Alzheimer's disease and its significant ramifications for novel anti-inflammatory treatments.神经炎症对阿尔茨海默病进展的影响及其对新型抗炎治疗的重要意义。
IBRO Neurosci Rep. 2025 May 22;18:771-782. doi: 10.1016/j.ibneur.2025.05.005. eCollection 2025 Jun.
3
Decoding mechanisms and protein markers in lung-brain axis.肺-脑轴中的解码机制和蛋白质标志物
Respir Res. 2025 May 19;26(1):190. doi: 10.1186/s12931-025-03272-z.
4
Higher plasma soluble TREM2 correlates with reduced cerebral tau accumulation in Alzheimer's disease.在阿尔茨海默病中，较高的血浆可溶性触发受体表达于髓样细胞2（TREM2）水平与大脑中tau蛋白积累减少相关。
Mol Psychiatry. 2025 Apr 1. doi: 10.1038/s41380-025-02976-4.
5
Neuroinflammatory fluid biomarkers in patients with Alzheimer's disease: a systematic literature review.阿尔茨海默病患者的神经炎症性体液生物标志物：一项系统文献综述。
Mol Psychiatry. 2025 Jun;30(6):2783-2798. doi: 10.1038/s41380-025-02939-9. Epub 2025 Mar 6.
6
Biological signatures in the Alzheimer's continuum discriminate between diagnosis-related and -unrelated associations to ATN categories.阿尔茨海默病连续体中的生物学特征区分了与ATN分类相关和不相关的诊断关联。
Brain Commun. 2025 Feb 21;7(2):fcaf078. doi: 10.1093/braincomms/fcaf078. eCollection 2025.
7
Peripheral and central neuroimmune mechanisms in Alzheimer's disease pathogenesis.阿尔茨海默病发病机制中的外周和中枢神经免疫机制。
Mol Neurodegener. 2025 Feb 21;20(1):22. doi: 10.1186/s13024-025-00812-5.
8
Unlocking early detection of Alzheimer's disease: The emerging role of nanomaterial-based optical sensors.解锁阿尔茨海默病的早期检测：基于纳米材料的光学传感器的新兴作用。
J Food Drug Anal. 2024 Sep 13;32(3):296-324. doi: 10.38212/2224-6614.3520.
9
A Computational Approach in the Systematic Search of the Interaction Partners of Alternatively Spliced TREM2 Isoforms.一种在系统搜索 TREM2 异构体的互作伙伴中的计算方法。
Int J Mol Sci. 2024 Sep 6;25(17):9667. doi: 10.3390/ijms25179667.
10
Associations between Microglia and Astrocytic Proteins and Tau Biomarkers across the Continuum of Alzheimer's Disease.阿尔茨海默病连续体中微胶质细胞和星形胶质细胞蛋白与 Tau 生物标志物的关联。
Int J Mol Sci. 2024 Jul 9;25(14):7543. doi: 10.3390/ijms25147543.

本文引用的文献

1
TREM2 expression in the human brain: a marker of monocyte recruitment?TREM2 在人脑中的表达：单核细胞募集的标志物？
Brain Pathol. 2018 Sep;28(5):595-602. doi: 10.1111/bpa.12564. Epub 2017 Oct 30.
2
TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant.TREM2 通过在 H157-S158 键处的裂解进行脱落，阿尔茨海默病相关的 H157Y 变体加速了这一过程。
EMBO Mol Med. 2017 Oct;9(10):1366-1378. doi: 10.15252/emmm.201707673.
3
An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function.一种与阿尔茨海默病相关的 TREM2 变异位于 ADAM 切割位点，影响其脱落和吞噬功能。
EMBO Mol Med. 2017 Oct;9(10):1356-1365. doi: 10.15252/emmm.201707672.
4
TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease.触发受体表达于髓细胞2（TREM2）维持阿尔茨海默病中小胶质细胞的代谢适应性。
Cell. 2017 Aug 10;170(4):649-663.e13. doi: 10.1016/j.cell.2017.07.023.
5
CSF/serum albumin ratio in dementias: a cross-sectional study on 1861 patients.痴呆患者脑脊液/血清白蛋白比值：对1861例患者的横断面研究
Neurobiol Aging. 2017 Nov;59:1-9. doi: 10.1016/j.neurobiolaging.2017.06.028. Epub 2017 Jul 11.
6
The Alzheimer's disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway.阿尔茨海默病风险因素载脂蛋白E和触发受体表达分子2（TREM2）在一条受体信号通路中相互关联。
J Neuroinflammation. 2017 Mar 21;14(1):59. doi: 10.1186/s12974-017-0835-4.
7
Soluble TREM2 induces inflammatory responses and enhances microglial survival.可溶性触发受体2（TREM2）诱导炎症反应并增强小胶质细胞存活。
J Exp Med. 2017 Mar 6;214(3):597-607. doi: 10.1084/jem.20160844. Epub 2017 Feb 16.
8
Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease.阿尔茨海默病小鼠模型中TREM2缺乏对疾病进展的依赖性影响
J Neurosci. 2017 Jan 18;37(3):637-647. doi: 10.1523/JNEUROSCI.2110-16.2016.
9
Increased blood-brain barrier permeability is associated with dementia and diabetes but not amyloid pathology or APOE genotype.血脑屏障通透性增加与痴呆症和糖尿病有关，但与淀粉样蛋白病理或载脂蛋白E基因型无关。
Neurobiol Aging. 2017 Mar;51:104-112. doi: 10.1016/j.neurobiolaging.2016.11.017. Epub 2016 Dec 5.
10
Early changes in CSF sTREM2 in dominantly inherited Alzheimer's disease occur after amyloid deposition and neuronal injury.在显性遗传性阿尔茨海默病中，CSF sTREM2 的早期变化发生在淀粉样蛋白沉积和神经元损伤之后。
Sci Transl Med. 2016 Dec 14;8(369):369ra178. doi: 10.1126/scitranslmed.aag1767.