Turk J Med Sci. 2019 Apr 18;49(2):617-623. doi: 10.3906/sag-1812-139.
BACKGROUND/AIM: Psoriasis is a chronic inflammatory disease. The effect of psoriasis on the cardiovascular system has not been studied in children before. We studied ventricular strain and vascular functions to assess early cardiovascular effects of psoriasis during childhood.
The study population consisted of 20 psoriatic and 20 age- and sex-matched control subjects. Two-dimensional echocardiography images, longitudinal and global strain, and carotid and brachial ultrasound studies were performed.
The mean age of psoriatic children was 14 ± 0.89 years and that of the controls was 14.05 ± 0.88. There were significant increases in terms of interventricular septum diastolic and left ventricular posterior wall diastolic diameter and decreases in mitral E, mitral A, and E/A values between groups. Tissue Doppler imaging revealed significant differences between groups in terms of lateral annulus E’, A’, E’/A, isovolumetric contraction time, and ejection time. Aortic stiffness was significantly higher and global circumferential strain and longitudinal strain were significantly lower in the psoriasis group. Carotid intima media thickness and flow-mediated dilatation did not differ significantly between the groups.
Cardiac left ventricular and arterial functions are affected in psoriatic children and may be an alarming sign of atherosclerotic heart disease in the long term. Early detection of these changes may be helpful for eliminating other risk factors.
背景/目的：银屑病是一种慢性炎症性疾病。以前尚未研究过儿童银屑病对心血管系统的影响。我们研究了心室应变和血管功能，以评估儿童期银屑病的早期心血管影响。
研究人群包括 20 名银屑病患者和 20 名年龄和性别匹配的对照者。进行了二维超声心动图图像、纵向和整体应变以及颈动脉和肱动脉超声研究。
银屑病患儿的平均年龄为 14 ± 0.89 岁，对照组为 14.05 ± 0.88 岁。两组间室间隔舒张期和左心室后壁舒张期直径均有显著增加，二尖瓣 E、二尖瓣 A 和 E/A 值均有显著降低。组织多普勒成像显示两组间外侧环 E’、A’、E’/A、等容收缩时间和射血时间有显著差异。银屑病组的主动脉僵硬度显著升高，整体环向应变和纵向应变显著降低。颈动脉内膜中层厚度和血流介导的扩张在两组间无显著差异。
银屑病患儿的左心室和动脉功能受到影响，这可能是长期动脉粥样硬化性心脏病的一个警告信号。早期发现这些变化可能有助于消除其他危险因素。
