Gisondi Paolo, Fantin Francesco, Del Giglio Micol, Valbusa Filippo, Marino Francesca, Zamboni Mauro, Girolomoni Giampiero
Section of Dermatology and Venereology, Department of Biomedical and Surgical Sciences, University of Verona, Verona, Italy.
Dermatology. 2009;218(2):110-3. doi: 10.1159/000182256. Epub 2008 Dec 6.
Patients with moderate to severe chronic plaque psoriasis have a higher prevalence of cardiovascular risk factors and atherosclerosis. Arterial stiffness is a measure of endothelial dysfunction and an independent predictor of cardiovascular events.
To investigate whether chronic plaque psoriasis is associated with an increased arterial stiffness.
A cross-sectional study on 39 adult patients with moderate to severe chronic plaque psoriasis and 38 control patients with skin diseases other than psoriasis was conducted. Arterial stiffness was assessed by carotid-femoral and carotid-radial pulse wave velocity (PWVcf, PWVcr).
PWVcf was significantly higher in patients with psoriasis than in controls (means +/- SD; 8.88 +/- 1.96 vs. 7.57 +/- 1.34 m/s; p = 0.001). Difference was still significant after adjustment for age, gender, smoking status, hypertension and body mass index (8.78 +/- 1.98 vs. 7.78 +/- 2.0 m/s; p = 0.03). There was a positive correlation between PWVcf and years of psoriasis duration (r = 0.58; p = 0.0001), but not with disease severity.
Moderate to severe chronic plaque psoriasis may be independently associated with increased arterial stiffness. Psoriasis duration could be a risk factor for arterial stiffness and atherosclerosis.
中重度慢性斑块状银屑病患者心血管危险因素及动脉粥样硬化的患病率更高。动脉僵硬度是内皮功能障碍的一个指标，也是心血管事件的独立预测因子。
研究慢性斑块状银屑病是否与动脉僵硬度增加有关。
对39例中重度慢性斑块状银屑病成年患者和38例非银屑病皮肤病对照患者进行了一项横断面研究。通过颈股和颈桡脉搏波速度（PWVcf、PWVcr）评估动脉僵硬度。
银屑病患者的PWVcf显著高于对照组（均值±标准差；8.88±1.96 vs. 7.57±1.34 m/s；p = 0.001）。在调整年龄、性别、吸烟状况、高血压和体重指数后，差异仍然显著（8.78±1.98 vs. 7.78±2.0 m/s；p = 0.03）。PWVcf与银屑病病程呈正相关（r = 0.58；p = 0.0001），但与疾病严重程度无关。
中重度慢性斑块状银屑病可能与动脉僵硬度增加独立相关。银屑病病程可能是动脉僵硬度和动脉粥样硬化的一个危险因素。
