Aaron S, Davis P, Bertouch J
Arthritis Rheum. 1986 Dec;29(12):1515-7. doi: 10.1002/art.1780291214.
We studied the clinical courses of 9 patients who developed acute gold-induced neutropenia with marrow aplasia. Eight of these carried HLA-DR4, compared with only 2 of 9 who had mild, chronic, isolated neutropenia (P less than 0.05). Only 1 of 9 patients with myelotoxicity carried HLA-DR3. We conclude that these groups are immunogenetically distinct, and that HLA-DR3 is not a significant risk factor for severe gold-induced neutropenia.
我们研究了9例发生急性金诱导的中性粒细胞减少伴骨髓再生障碍患者的临床病程。其中8例携带HLA - DR4，而9例患有轻度、慢性、孤立性中性粒细胞减少症的患者中只有2例携带该基因（P小于0.05）。9例发生骨髓毒性的患者中只有1例携带HLA - DR3。我们得出结论，这些组在免疫遗传学上是不同的，并且HLA - DR3不是严重金诱导的中性粒细胞减少症的重要危险因素。
