人类白细胞抗原DR抗原与金毒性
HLA DR antigens and gold toxicity.
作者信息
Gran J T, Husby G, Thorsby E
出版信息
Ann Rheum Dis. 1983 Feb;42(1):63-6. doi: 10.1136/ard.42.1.63.
Abstract
One hundred and thirty-two patients with rheumatoid arthritis treated with gold have been studied for possible associations between HLA DR antigens and different adverse reactions occurring during such therapy. Patients possessing HLA DR3 had a significantly greater frequency of side effects than patients lacking this antigen. It was particularly noticed that DR3 positive patients on gold treatment had an 11 times higher risk of getting proteinuria than those without DR3. The lowest frequency of side effects was seen in DR7 positives. No significant differences between the DR antigen groups with respect to skin eruptions, liver reactions, or leucopenia were evident.
摘要
对132例接受金制剂治疗的类风湿性关节炎患者进行了研究，以探讨HLA DR抗原与该治疗过程中发生的不同不良反应之间可能存在的关联。携带HLA DR3的患者出现副作用的频率明显高于缺乏该抗原的患者。特别值得注意的是，接受金制剂治疗的DR3阳性患者出现蛋白尿的风险是未携带DR3患者的11倍。DR7阳性患者出现副作用的频率最低。在皮疹、肝脏反应或白细胞减少方面，各DR抗原组之间没有明显差异。
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