Dong Jianyu, Liu Long, Ji Xuyu, Shang Qian, Liu Lixin, Su Lebin, Chen Bing, Kan Ruifeng, Zhou Yongbo, Yin Shuang-Feng, Han Li-Biao
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering , Hunan University , Changsha 410082 , China.
Department of Educational Science , Hunan First Normal University , Changsha 410205 , China.
Org Lett. 2019 May 3;21(9):3198-3203. doi: 10.1021/acs.orglett.9b00922. Epub 2019 Apr 18.
Oxidative C-C/P-H cross-coupling is achieved via Pd-catalyzed decarbonylative cross-coupling of aroylhydrazides with P(O)H compounds. The unique cooperative reaction system, especially the Brønsted acid and bidentate phosphine ligand, allows the selective activation of the inert C-C bond and the suppression of the undesired oxidation and coordination of >P(O)-H compounds, leading to a general oxidative synthesis of aryl phosphorus compounds from easily available substrates.
通过钯催化芳酰肼与P（O）H化合物的脱羰交叉偶联实现氧化C-C/P-H交叉偶联。独特的协同反应体系，特别是布朗斯特酸和双齿膦配体，能够选择性地活化惰性C-C键，并抑制> P（O）-H化合物不期望的氧化和配位，从而从容易获得的底物出发，实现芳基磷化合物的通用氧化合成。
