Young Juan J, Balachandran Silpa, Garg Garima, Balasubramaniam Meera, Gupta Aarti, Tampi Deena J, Tampi Rajesh R
Department of Psychiatry, Case Western Reserve University School of Medicine, MetroHealth, 2500 MetroHealth Drive, Cleveland, OH 44109, USA.
Department of Psychiatry, New York University School of Medicine, 462 First Avenue, New York, NY 10016, USA.
Neurodegener Dis Manag. 2019 Apr;9(2):107-118. doi: 10.2217/nmt-2018-0044. Epub 2019 Apr 18.
Premorbid personality traits have been implicated as risk factors for the development of behavioral and psychological symptoms of dementia (BPSD), although there is a paucity of studies investigating this relationship. In this narrative review, a number of studies found that premorbid neuroticism has consistently been observed to have a significant association with the development of BPSD symptoms while premorbid conscientiousness, extraversion, openness and agreeableness may be protective factors against future BPSD symptoms. In conclusion, premorbid personality traits appear to affect the risk of BPSD symptoms among individuals with dementia.
病前人格特质已被认为是痴呆行为和心理症状（BPSD）发生的风险因素，尽管研究这种关系的研究很少。在这篇叙述性综述中，多项研究发现，病前神经质一直被观察到与BPSD症状的发生有显著关联，而病前尽责性、外向性、开放性和宜人性可能是预防未来BPSD症状的保护因素。总之，病前人格特质似乎会影响痴呆患者出现BPSD症状的风险。
