[检测多发性骨髓瘤患者血清补体C3和C4的意义]

[Significance of Detecting Serum Complement C3 and C4 in Patients with Multiple Myeloma].

作者信息

Li Cheng-Jun, Xia Hai-Long, Wu Yan-Ming, Ding Gang, Xu Dan-Dan

机构信息

Department of Hematology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China,Department of Hematology, Chaohu Hospital Affiliated to Anhui Medical University，Chaohu 238000, Anhui Province, China.

出版信息

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2019 Apr;27(2):472-476. doi: 10.19746/j.cnki.issn.1009-2137.2019.02.026.

DOI:10.19746/j.cnki.issn.1009-2137.2019.02.026

PMID:30998156

Abstract

OBJECTIVE

To investigate the significance of detecting serum complement C3 and C4 in patients with multiple myeloma (MM) and to explore its correlation with myeloma bone disease (MBD).

METHODS

The levels of serum complement C3 and C4 in 69 MM patients and 30 healthy people were examined by scatter nephelometry. The bone density of L1-4 vertebral body, bilateral femoral neck and bilateral hip joints were measured by dual energy bone density meter (DXA).

RESULTS

The levels of serum complement C3 and C4 in MM patients significantly increased in comparison with that in healthy people (P＜0.01). The patients in advanced clinical stage exhibited a higher levels of C3 and C4 than those in stable stage (P＜0.01). In addition, the patients with grade C of MBD had a higher levels of serum complement C3 and C4 than those in patients with grade A and B of MBD (P＜0.01). The levels of serum complement C3 and C4 in MM patients negatively correlated with bone density in L1-4 vertebral body, bilateral femoral necks and hip joints. The correlation coefficients were r=-0.938, r=-0.659, r=-0.745, r=-0.748, r=-0.596 in complement C3 and r=-0.908, r=-0.623, r=-0.710, r=-0.714, r=-0.595 in complement C4, respectively.

CONCLUSION

The levels of complement C3 and C4 positively correlate with the severity of bone disease and bone density in MM patients, which suggests that complement C3 and C4 plays important roles in the development of MBD. The levels of serum C3 and C4 may be the sensitive biomarkers of MBD.

摘要

目的

探讨检测多发性骨髓瘤（MM）患者血清补体C3和C4的意义，并探讨其与骨髓瘤骨病（MBD）的相关性。

方法

采用散射比浊法检测69例MM患者和30例健康人的血清补体C3和C4水平。采用双能骨密度仪（DXA）测量L1-4椎体、双侧股骨颈和双侧髋关节的骨密度。

结果

MM患者血清补体C3和C4水平明显高于健康人（P＜0.01）。临床晚期患者的C3和C4水平高于稳定期患者（P＜0.01）。此外，MBD C级患者的血清补体C3和C4水平高于MBD A级和B级患者（P＜0.01）。MM患者血清补体C3和C4水平与L1-4椎体、双侧股骨颈和髋关节的骨密度呈负相关。补体C3的相关系数分别为r=-0.938、r=-0.659、r=-0.745、r=-0.748、r=-0.596，补体C4的相关系数分别为r=-0.908、r=-0.623、r=-0.710、r=-0.714、r=-0.595。