Vemuri Pooja Y, Patureau Frederic W
Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany.
Org Lett. 2021 May 21;23(10):3902-3907. doi: 10.1021/acs.orglett.1c01034. Epub 2021 May 11.
Nitrogen-nitrogen bond containing motifs are ubiquitous in bioactive compounds and organic materials. However, intermolecular hetero-selective N-H/N-H oxidative coupling reactions remain very challenging and largely unexplored. Here, we report an unprecedented, simple and hetero-selective cross-dehydrogenative N-N coupling of amides and benzotriazoles, utilizing only a hypervalent iodine species as the terminal oxidant. The scope and mechanistic investigations are discussed.
含氮-氮键的结构单元在生物活性化合物和有机材料中普遍存在。然而，分子间的杂原子选择性N-H/N-H氧化偶联反应仍然极具挑战性，且在很大程度上尚未得到探索。在此，我们报道了一种前所未有的、简单的酰胺与苯并三唑的杂原子选择性交叉脱氢N-N偶联反应，仅使用高价碘物种作为终端氧化剂。文中讨论了该反应的适用范围和反应机理研究。
