Department of Pharmaceutics School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Dermatology School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
J Dermatolog Treat. 2020 Nov;31(7):730-733. doi: 10.1080/09546634.2019.1606394. Epub 2019 May 15.
Erythromycin is an effective topical antibiotic for treating mild-to-moderate inflammatory acne vulgaris, especially papules acne during puberty as well as papules - pustular acne in adult women. Erythromycin is a macrolide antibiotic that has long been used as a topical dosage form to treat acne. It has favorable effects in resolving inflammatory acne lesions not only by reducing Propioni bacterium acnes density, but also by directly inhibiting neutrophil chemotactic factors and reactive oxygen species (ROS) production. Zinc, a metallic element has bacteriostatic activity against Propioni bacterium acnes. Combining zinc with antibiotic (erythromycin) can reduce antibiotic resistance and increase antibiotic absorption in-to the skin. In the present study, erythromycin (2% w/v) with zinc acetate (1.2% w/v) as 'topical gel' and erythromycin (2% w/v) gel alone were evaluated for treating mild to moderate inflammatory acne vulgaris. This double-blind study was carried out on 102 patients 13-25 years of age, divided into two groups. The group A received erythromycin and group B received erythromycin with zinc acetate topical gels during 3 weeks. Acne grading and lesion counts for comedones, papules and pustules were performed during each visit zero, first, second and third weeks. Erythromycin treatment (with zinc acetate) gel showed to be more effective than erythromycin (alone) gel with respect to reducing the number of acne lesions and severity grade of acne.Number of lesions and severity of acne were significantly reduced at the end of 3rd week in both groups ( < .001). In conclusion, it can be stated that erythromycin with and without zinc acetate was clinically effective, and both formulations produced a significant reductions in acne grading as well as inflamed and noninflamed lesion counts ( < .000). Statistically, there was no significant difference between formulation A and B.
红霉素是一种有效的局部抗生素，可用于治疗轻度至中度炎症性寻常痤疮，尤其是青春期的丘疹性痤疮和成年女性的丘疹脓疱性痤疮。红霉素是一种大环内酯类抗生素，长期以来一直被用作局部剂型来治疗痤疮。它不仅通过降低痤疮丙酸杆菌密度，而且通过直接抑制中性粒细胞趋化因子和活性氧（ROS）的产生，对解决炎症性痤疮病变具有良好的效果。锌是一种对痤疮丙酸杆菌具有抑菌活性的金属元素。将锌与抗生素（红霉素）结合使用可以降低抗生素耐药性并增加抗生素在皮肤中的吸收。在本研究中，评估了醋酸锌（1.2%w/v）与红霉素（2%w/v）的组合作为“局部凝胶”以及单独使用红霉素（2%w/v）凝胶治疗轻度至中度炎症性寻常痤疮的效果。这项双盲研究在 102 名 13-25 岁的患者中进行，将他们分为两组。A 组接受红霉素治疗，B 组接受含有醋酸锌的红霉素局部凝胶治疗，为期 3 周。在每次就诊时（零周、第一周、第二周和第三周）对粉刺、丘疹和脓疱的痤疮分级和病变计数进行评估。与单独使用红霉素凝胶相比，含有醋酸锌的红霉素凝胶在减少痤疮病变数量和痤疮严重程度方面表现出更有效。在第 3 周末，两组的病变数量和痤疮严重程度均显著降低（<0.001）。总之，可以说红霉素与不含醋酸锌的红霉素一样具有临床疗效，两种制剂均可显著降低痤疮分级以及炎症性和非炎症性病变计数（<0.000）。统计学上，制剂 A 和 B 之间没有显著差异。
