Gu Lei, Chen Na, Li Zhenhua, Zhang Fenglei, Wang Xiaotian
Department of Cardiology, People's Hospital of Dongying.
Department of Ultrasound, Shengli Oilfield Central Hospital, Dongying, China.
Coron Artery Dis. 2019 Nov;30(7):542-546. doi: 10.1097/MCA.0000000000000745.
To investigate the association of Wnt1-inducible signaling pathway protein 1 (WISP1) concentrations in circulation with the presence and severity of coronary artery disease (CAD).
A total of 120 consecutive participants who underwent coronary angiography between May 2017 and July 2018 at our center were enrolled. Participants were divided into two groups based on the presence of CAD. Serum WISP1 levels were measured using enzyme-linked immunosorbent assay. Univariate and multivariate analyses were used to determine the association between variables and the presence of CAD.
The average age of the study population was 59.8 years, 66.7% were male, and 58.3% were positive for CAD. Serum WISP1 levels were significantly higher in patients with CAD than non-CAD group (339.8 vs. 322.4 pg/ml, P = 0.012). Moreover, a stepwise increase in serum WISP1 levels was observed with the number of diseased vessels (zero-vessel, one-vessel, two-vessel, and three-vessel disease: 322.4, 324.7, 345.4, and 392.1 pg/ml, respectively, P < 0.001) or Gensini score (r = 0.376, P < 0.001). Importantly, serum WISP1 levels were positively associated with the presence of CAD ( β = 1.011, 95% confidence interval: 1.001-1.021, P = 0.026). This association persisted after adjusting for age, sex, hypertension, type 2 diabetes mellitus, hypercholesterolemia, smoking, and high-sensitivity C-reactive protein ( β = 1.011, 95% confidence interval: 1.000-1.021, P = 0.047). In addition, serum WISP1 concentrations were positively correlated with BMI (r = 0.212, P = 0.020), insulin (r = 0.237, P = 0.009), and homeostatic model assessment for insulin resistance (r = 0.223, P = 0.014).
We demonstrated for the first time that serum WISP1 concentration is associated with the presence and severity of CAD.
探讨循环中Wnt1诱导信号通路蛋白1（WISP1）浓度与冠状动脉疾病（CAD）的存在及严重程度之间的关联。
纳入2017年5月至2018年7月在本中心连续接受冠状动脉造影的120名参与者。根据是否存在CAD将参与者分为两组。采用酶联免疫吸附测定法测量血清WISP1水平。单因素和多因素分析用于确定变量与CAD存在之间的关联。
研究人群的平均年龄为59.8岁，男性占66.7%，CAD阳性率为58.3%。CAD患者的血清WISP1水平显著高于非CAD组（339.8对322.4 pg/ml，P = 0.012）。此外，随着病变血管数量（零支血管、一支血管、两支血管和三支血管病变：分别为322.4、324.7、345.4和392.1 pg/ml，P < 0.001）或Gensini评分（r = 0.376，P < 0.001）的增加，血清WISP1水平呈逐步上升趋势。重要的是，血清WISP1水平与CAD的存在呈正相关（β = 1.011，95%置信区间：1.001 - 1.021，P = 0.026）。在调整年龄、性别、高血压、2型糖尿病、高胆固醇血症、吸烟和高敏C反应蛋白后，这种关联仍然存在（β = 1.011，95%置信区间：1.000 - 1.021，P = 0.047）。此外，血清WISP1浓度与体重指数（r = 0.212，P = 0.020）、胰岛素（r = 0.237，P = 0.009）以及胰岛素抵抗的稳态模型评估（r = 0.223，P = 0.014）呈正相关。
我们首次证明血清WISP1浓度与CAD的存在及严重程度相关。
