The Key Laboratory of Experimental Teratology of the Ministry of Education, School of Basic Medical Science, Shandong University, Jinan, Shandong 250012, China; The Jackson Laboratory, Bar Harbor, ME 04609, USA.
The Jackson Laboratory, Bar Harbor, ME 04609, USA.
Pharmacol Ther. 2019 Aug;200:42-54. doi: 10.1016/j.pharmthera.2019.04.005. Epub 2019 Apr 16.
Mesenchymal stem cells (MSCs) are multipotent tissue stem cells that differentiate into a number of mesodermal tissue types, including osteoblasts, adipocytes, chondrocytes and myofibroblasts. MSCs were originally identified in the bone marrow (BM) of humans and other mammals, but recent studies have shown that they are multilineage progenitors in various adult organs and tissues. MSCs that localize at perivascular sites function to rapidly respond to external stimuli and coordinate with the vascular and immune systems to accomplish the wound healing process. Cancer, considered as wounds that never heal, is also accompanied by changes in MSCs that parallels the wound healing response. MSCs are now recognized as key players at distinct steps of tumorigenesis. In this review, we provide an overview of the function of MSCs in wound healing and cancer progression with the goal of providing insight into the development of novel MSC-manipulating strategies for clinical cancer treatment.
间充质干细胞（MSCs）是多能组织干细胞，可分化为多种中胚层组织类型，包括成骨细胞、脂肪细胞、软骨细胞和成肌纤维细胞。MSCs 最初在人类和其他哺乳动物的骨髓（BM）中被鉴定出来，但最近的研究表明，它们是各种成年器官和组织中的多谱系祖细胞。定位于血管周围部位的 MSCs 能够快速响应外部刺激，并与血管和免疫系统协调，完成伤口愈合过程。癌症被认为是永不愈合的伤口，同时也伴随着 MSCs 的变化，与伤口愈合反应平行。MSCs 现在被认为是肿瘤发生的不同阶段的关键参与者。在这篇综述中，我们概述了 MSCs 在伤口愈合和癌症进展中的功能，旨在为开发用于临床癌症治疗的新型 MSC 操作策略提供思路。
