• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

静脉注射免疫球蛋白抵抗型川崎病的预测因素及管理

Predictors and management of intravenous immunoglobulin-resistant Kawasaki disease.

作者信息

Song Min Seob

机构信息

Department of Pediatrics, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.

出版信息

Korean J Pediatr. 2019 Apr;62(4):119-123. doi: 10.3345/kjp.2019.00150. Epub 2019 Mar 15.

DOI:10.3345/kjp.2019.00150
PMID:30999718
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6477551/
Abstract

Kawasaki disease (KD) is a systemic vasculitis that mainly affects younger children. Intravenous immunoglobulin (IVIG) resistant cases are at increasing risk for coronary artery complications. The strategy on prediction of potential nonresponders and treatment of IVIG-resistant patients is now controversial. In this review the definition and predictors of IVIG-resistant KD and current evidence to guide management are discussed.

摘要

川崎病（KD）是一种主要影响幼儿的全身性血管炎。静脉注射免疫球蛋白（IVIG）抵抗型病例发生冠状动脉并发症的风险不断增加。预测潜在无反应者以及治疗IVIG抵抗型患者的策略目前存在争议。在这篇综述中，将讨论IVIG抵抗型KD的定义、预测因素以及指导治疗的现有证据。

相似文献

1
Predictors and management of intravenous immunoglobulin-resistant Kawasaki disease.静脉注射免疫球蛋白抵抗型川崎病的预测因素及管理
Korean J Pediatr. 2019 Apr;62(4):119-123. doi: 10.3345/kjp.2019.00150. Epub 2019 Mar 15.
2
Predictors of intravenous immunoglobulin resistance and coronary artery aneurysm in patients with Kawasaki disease.川崎病患者静脉注射免疫球蛋白抵抗及冠状动脉瘤的预测因素
Paediatr Int Child Health. 2018 Aug;38(3):209-212. doi: 10.1080/20469047.2018.1471381. Epub 2018 May 17.
3
Predictors for intravenous immunoglobulin resistance and coronary artery lesions in Kawasaki disease.川崎病中静脉注射免疫球蛋白抵抗及冠状动脉病变的预测因素
Pediatr Rheumatol Online J. 2017 Mar 21;15(1):17. doi: 10.1186/s12969-017-0149-1.
4
Kawasaki disease: a comprehensive review of treatment options.川崎病：治疗选择的全面综述
J Clin Pharm Ther. 2015 Dec;40(6):620-5. doi: 10.1111/jcpt.12334. Epub 2015 Nov 7.
5
Kawasaki disease in Turkish children: a single center experience with emphasis on intravenous immunoglobulin resistance and giant coronary aneurysms.土耳其儿童川崎病：单中心经验，重点关注静脉注射免疫球蛋白抵抗和巨大冠状动脉瘤
Turk J Pediatr. 2019;61(5):648-656. doi: 10.24953/turkjped.2019.05.002.
6
Predictors of intravenous immunoglobulin-resistant Kawasaki disease in children: a meta-analysis of 4442 cases.预测儿童静脉注射免疫球蛋白抵抗川崎病的因素：4442 例病例的荟萃分析。
Eur J Pediatr. 2018 Aug;177(8):1279-1292. doi: 10.1007/s00431-018-3182-2. Epub 2018 Jun 8.
7
Delayed intravenous immunoglobulin treatment increased the risk of coronary artery lesions in children with Kawasaki disease at different status.延迟静脉注射免疫球蛋白治疗增加了不同状态川崎病患儿冠状动脉病变的风险。
Postgrad Med. 2018 May;130(4):442-447. doi: 10.1080/00325481.2018.1468712. Epub 2018 May 10.
8
Risk factors of immunoglobulin resistance and coronary complications in children with Kawasaki disease.川崎病患儿免疫球蛋白抵抗及冠状动脉并发症的危险因素
Kardiol Pol. 2017;75(3):261-266. doi: 10.5603/KP.a2016.0179. Epub 2016 Dec 20.
9
Homozygous of Gene rs1751034 C Allele Is Related to Increased Risk of Intravenous Immunoglobulin Resistance in Kawasaki Disease.基因rs1751034 C等位基因纯合与川崎病静脉注射免疫球蛋白抵抗风险增加有关。
Front Genet. 2021 Mar 15;12:510350. doi: 10.3389/fgene.2021.510350. eCollection 2021.
10
Neutrophil-to-Lymphocyte Ratio Predicts Intravenous Immunoglobulin-Resistance in Infants Under 12-Months Old With Kawasaki Disease.中性粒细胞与淋巴细胞比值可预测12个月以下川崎病婴儿对静脉注射免疫球蛋白的耐药性。
Front Pediatr. 2019 Mar 19;7:81. doi: 10.3389/fped.2019.00081. eCollection 2019.

引用本文的文献

1
Macrophage Activation Syndrome in Kawasaki Disease: Insights from a Systematic Literature Review on Diagnosis, Clinical Features, and Treatment.川崎病中的巨噬细胞活化综合征：关于诊断、临床特征及治疗的系统文献综述见解
Children (Basel). 2025 Mar 11;12(3):349. doi: 10.3390/children12030349.
2
Intravenous immunoglobulin-resistant Kawasaki disease: Risk factors in children in a middle-income country.静脉注射免疫球蛋白抵抗型川崎病：中等收入国家儿童的危险因素
Ann Pediatr Cardiol. 2023 Mar-Apr;16(2):102-108. doi: 10.4103/apc.apc_159_22. Epub 2023 Aug 16.
3
Predictors and a novel predictive model for intravascular immunoglobulin resistance in Kawasaki disease.川崎病血管内免疫球蛋白抵抗的预测因子及新型预测模型。
Ital J Pediatr. 2023 Sep 25;49(1):126. doi: 10.1186/s13052-023-01531-7.
4
Identification of key signaling pathways and hub genes related to immune infiltration in Kawasaki disease with resistance to intravenous immunoglobulin based on weighted gene co-expression network analysis.基于加权基因共表达网络分析鉴定川崎病中与静脉注射免疫球蛋白抵抗相关的免疫浸润关键信号通路和枢纽基因。
Front Mol Biosci. 2023 May 30;10:1182512. doi: 10.3389/fmolb.2023.1182512. eCollection 2023.
5
A decision tree model for predicting intravenous immunoglobulin resistance and coronary artery involvement in Kawasaki disease.川崎病静脉注射免疫球蛋白抵抗和冠状动脉受累预测的决策树模型。
BMC Pediatr. 2022 Aug 5;22(1):474. doi: 10.1186/s12887-022-03533-6.
6
Etiological and pathophysiological enigmas of severe coronavirus disease 2019, multisystem inflammatory syndrome in children, and Kawasaki disease.2019年冠状病毒病重症、儿童多系统炎症综合征及川崎病的病因学和病理生理学谜团
Clin Exp Pediatr. 2022 Apr;65(4):153-166. doi: 10.3345/cep.2021.01270. Epub 2021 Nov 23.
7
Is there an association between intravenous immunoglobulin resistance and coronary artery lesion in Kawasaki disease?-Current evidence based on a meta-analysis.川崎病静脉注射免疫球蛋白抵抗与冠状动脉病变之间是否存在关联？——基于荟萃分析的现有证据。
PLoS One. 2021 Mar 25;16(3):e0248812. doi: 10.1371/journal.pone.0248812. eCollection 2021.

本文引用的文献

1
Infliximab Treatment for Intravenous Immunoglobulin-resistant Kawasaki Disease: a Multicenter Study in Korea.英夫利昔单抗治疗对静脉注射免疫球蛋白耐药的川崎病：韩国的一项多中心研究。
Korean Circ J. 2019 Feb;49(2):183-191. doi: 10.4070/kcj.2018.0214. Epub 2018 Nov 8.
2
Efficacy and safety of intravenous immunoglobulin plus prednisolone therapy in patients with Kawasaki disease (Post RAISE): a multicentre, prospective cohort study.静脉注射免疫球蛋白联合泼尼松龙治疗川崎病的疗效和安全性（Post RAISE）：一项多中心前瞻性队列研究。
Lancet Child Adolesc Health. 2018 Dec;2(12):855-862. doi: 10.1016/S2352-4642(18)30293-1. Epub 2018 Oct 16.
3
Profile of resistance to IVIG treatment in patients with Kawasaki disease and concomitant infection.川崎病合并感染患者对静脉注射免疫球蛋白治疗耐药的特征。
PLoS One. 2018 Oct 17;13(10):e0206001. doi: 10.1371/journal.pone.0206001. eCollection 2018.
4
A Decade of NT-proBNP in Acute Kawasaki Disease, from Physiological Response to Clinical Relevance.急性川崎病中NT-脑钠肽前体的十年：从生理反应到临床意义
Children (Basel). 2018 Oct 12;5(10):141. doi: 10.3390/children5100141.
5
Kawasaki disease: abnormal initial echocardiogram is associated with resistance to IV Ig and development of coronary artery lesions.川崎病：初始超声心动图异常与静脉注射免疫球蛋白抵抗及冠状动脉病变的发生相关。
Pediatr Rheumatol Online J. 2018 Jul 18;16(1):48. doi: 10.1186/s12969-018-0264-7.
6
Predictors of intravenous immunoglobulin-resistant Kawasaki disease in children: a meta-analysis of 4442 cases.预测儿童静脉注射免疫球蛋白抵抗川崎病的因素：4442 例病例的荟萃分析。
Eur J Pediatr. 2018 Aug;177(8):1279-1292. doi: 10.1007/s00431-018-3182-2. Epub 2018 Jun 8.
7
The use of interleukin 1 receptor antagonist (anakinra) in Kawasaki disease: A retrospective cases series.白细胞介素 1 受体拮抗剂（阿那白滞素）在川崎病中的应用：一项回顾性病例系列研究。
Autoimmun Rev. 2018 Aug;17(8):768-774. doi: 10.1016/j.autrev.2018.01.024. Epub 2018 Jun 6.
8
Clinical implications in laboratory parameter values in acute Kawasaki disease for early diagnosis and proper treatment.急性川崎病实验室参数值对早期诊断和恰当治疗的临床意义。
Korean J Pediatr. 2018 May;61(5):160-166. doi: 10.3345/kjp.2018.61.5.160. Epub 2018 May 28.
9
Infliximab for the Treatment of Refractory Kawasaki Disease: A Nationwide Survey in Japan.英夫利昔单抗治疗川崎病难治性病例：日本全国性调查。
J Pediatr. 2018 Apr;195:115-120.e3. doi: 10.1016/j.jpeds.2017.10.013. Epub 2017 Dec 7.
10
Clinical Outcomes of Low-Dose Methotrexate Therapy as a Second-Line Drug for Intravenous Immunoglobulin-Resistant Kawasaki Disease.低剂量甲氨蝶呤作为静脉注射免疫球蛋白耐药型川崎病二线药物的临床疗效
Yonsei Med J. 2018 Jan;59(1):113-118. doi: 10.3349/ymj.2018.59.1.113.