大米与……的发酵产物通过DAF-16在线虫中诱导抗衰老作用和热应激耐受性。（注：原文中“with”后面内容缺失）

Fermented product of rice with induces anti-aging effects and heat stress tolerance in nematodes via DAF-16.

作者信息

Sugawara Takaya, Furuhashi Tsubasa, Shibata Kenji, Abe Masayuki, Kikuchi Keita, Arai Masato, Sakamoto Kazuichi

机构信息

a Graduate School of Life and Environmental Sciences , University of Tsukuba , Tsukuba , Japan.

b The College of Biological Sciences , University of Tsukuba , Tsukuba , Japan.

出版信息

Biosci Biotechnol Biochem. 2019 Aug;83(8):1484-1489. doi: 10.1080/09168451.2019.1606696. Epub 2019 Apr 18.

DOI:10.1080/09168451.2019.1606696

PMID:30999822

Abstract

Rice kefiran is superior in functionality, has high concentration of mucilaginous polysaccharide, and low lipid content, compared to conventional kefiran. However, reports on its physiological functionality, especially studies on life expectancy and aging, in model organisms are rare. In this study, nematodes were used as model organisms that were fed rice kefiran, along with OP50, as a result of which, the lifespan of nematodes was extended and age-related retardation of mobility was suppressed. It also increased the heat stress resistance in nematodes. Experiments using daf-16 deletion mutant revealed that rice kefiran functions via DAF-16. Thus, this study revealed the longevity, anti-aging and heat stress tolerance effects of rice kefiran in nematodes.

摘要

与传统开菲尔粒多糖相比，大米开菲尔粒多糖在功能上更具优势，具有高浓度的粘性多糖和低脂质含量。然而，关于其生理功能的报道，特别是在模式生物中关于寿命和衰老的研究却很少。在本研究中，使用线虫作为模式生物，用大米开菲尔粒多糖和OP50喂养线虫，结果线虫的寿命延长，与年龄相关的运动迟缓受到抑制。它还提高了线虫的热应激抗性。使用daf-16缺失突变体进行的实验表明，大米开菲尔粒多糖通过DAF-16发挥作用。因此，本研究揭示了大米开菲尔粒多糖对线虫的长寿、抗衰老和热应激耐受作用。