Cai Jie, Chen Zhongxu, Wu Yixin, Chen Yajuan, Wang Jianqiang, Lin Qinlu, Liang Ying
Molecular Nutrition Branch, National Engineering Research Center of Rice and By-product Deep Processing, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, Hunan, China.
Food Funct. 2022 Mar 7;13(5):2427-2440. doi: 10.1039/d1fo03718h.
With the increased aging of the population, the extension of lifespan and the improvement of healthspan have become important. Our previous studies showed that the rice bran peptide KF-8 exerts an antioxidant effect in cells and mice. In this study, we evaluated the effects of KF-8 on the healthspan and lifespan of . We found that KF-8 prolonged the life of nematodes and showed no reproductive toxicity towards nematodes. In addition, KF-8 improved the motility of nematodes and resulted in an extended body length. Using hydrogen peroxide and juglone as stress inducers, we found that KF-8 improved the anti-stress ability of nematodes. In addition, KF-8 upregulated the expressions of skn-1, daf-16 and antioxidant genes. In addition, the life-prolonging effect of KF-8 was lost in skn-1 mutant strains and daf-16 mutant strains, indicating that KF-8 may exert anti-aging effects through skn-1 and daf-16.
随着人口老龄化加剧，延长寿命和改善健康寿命变得至关重要。我们之前的研究表明，米糠肽KF-8在细胞和小鼠中发挥抗氧化作用。在本研究中，我们评估了KF-8对[具体对象]健康寿命和寿命的影响。我们发现KF-8延长了线虫的寿命，并且对线虫没有生殖毒性。此外，KF-8改善了线虫的运动能力并导致体长延长。使用过氧化氢和胡桃醌作为应激诱导剂，我们发现KF-8提高了线虫的抗应激能力。此外，KF-8上调了skn-1、daf-16和抗氧化基因的表达。此外，KF-8在skn-1突变菌株和daf-16突变菌株中失去了延长寿命的作用，表明KF-8可能通过skn-1和daf-16发挥抗衰老作用。
