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通过疟疾研究进行培训:在利比里亚建立良好临床和实验室实践能力。

Training through malaria research: building capacity in good clinical and laboratory practice in Liberia.

机构信息

ISGlobal, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.

Saint Joseph's Catholic Hospital, Monrovia, Liberia.

出版信息

Malar J. 2019 Apr 17;18(1):136. doi: 10.1186/s12936-019-2767-1.

Abstract

BACKGROUND

Limited health research capacities (HRC) undermine a country's ability to identify and adequately respond to local health needs. Although numerous interventions to strengthen HRC have been conducted in Africa, there is a need to share the lessons learnt by funding organizations, institutes and researchers. The aim of this report is to identify best practices in HRC strengthening by describing a training programme conducted between 2016 and 2017 at the Saint Joseph's Catholic Hospital (SJCH) in Monrovia (Liberia).

METHODS

A call for trainees was launched at the SJCH, the Liberia Medicines and Health Products Regulatory Authority (LMHRA), the Ministry of Health and Social Welfare, the Mother Pattern College of Health Sciences (MPCHS) and community members. Selected trainees participated in four workshops on Good Clinical Laboratory Practice (GCLP), standard operating procedures (SOP) and scientific communication, as well as in a 5-months eLearning mentoring programme. After the training, a collectively-designed research project on malaria was conducted.

RESULTS

Twenty-one of the 28 trainees (14 from the SJCH, 3 from LMHRA, one from MPCHS, and 10 community representatives) completed the programme satisfactorily. Pre- and post-training questionnaires completed by 9 of the trainees showed a 14% increase in the percentage of correct answers. Trainees participated in a mixed-methods cross-sectional study of Plasmodium falciparum infection among pregnant women at the SJCH. Selected trainees disseminated activities and research outcomes in three international meetings and three scientific publications.

CONCLUSION

This training-through-research programme successfully involved SJCH staff and community members in a practical research exercise on malaria during pregnancy. The challenge is to ensure that the SJCH remains active in research. Harmonization of effectiveness indicators for HRC initiatives would strengthen the case for investing in such efforts.

摘要

背景

有限的卫生研究能力(HRC)削弱了一个国家识别和充分应对当地卫生需求的能力。尽管在非洲已经进行了许多加强 HRC 的干预措施,但有必要分享供资组织、机构和研究人员吸取的经验教训。本报告的目的是通过描述 2016 年至 2017 年在蒙罗维亚圣约瑟夫天主教医院(SJCH)进行的一项培训计划,确定加强 HRC 的最佳实践。

方法

在 SJCH、利比里亚药品和保健产品管理局(LMHRA)、卫生部和社会福利部、母型学院保健科学(MPCHS)和社区成员中发布了培训学员的招聘通知。选定的学员参加了四次关于良好临床实验室实践(GCLP)、标准操作规程(SOP)和科学交流的讲习班,以及五个月的电子学习辅导计划。培训结束后,共同设计了一个关于疟疾的研究项目。

结果

28 名学员中的 21 名(14 名来自 SJCH,3 名来自 LMHRA,1 名来自 MPCHS,10 名社区代表)圆满完成了该计划。9 名学员完成的培训前后调查问卷显示,正确答案的百分比增加了 14%。学员们参加了 SJCH 孕妇中恶性疟原虫感染的混合方法横断面研究。选定的学员在三次国际会议和三次科学出版物中传播了活动和研究成果。

结论

该培训-研究计划成功地使 SJCH 工作人员和社区成员参与了一项关于孕妇疟疾的实际研究。挑战是确保 SJCH 继续积极从事研究工作。协调 HRC 举措的有效性指标将加强为这些努力投资的理由。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b168/6471755/0ec4f8d3d7b2/12936_2019_2767_Fig1_HTML.jpg

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