斑马鱼（Danio rerio）性别决定和维持的遗传调控。
Genetic regulation of sex determination and maintenance in zebrafish (Danio rerio).
机构信息
Molecular and Cellular Biology, University of California, Davis, CA, United States.
Molecular and Cellular Biology, University of California, Davis, CA, United States.
出版信息
Curr Top Dev Biol. 2019;134:119-149. doi: 10.1016/bs.ctdb.2019.02.004. Epub 2019 Mar 21.
Abstract
Over the last several decades zebrafish (Danio rerio) has become a major model organism for the study of vertebrate development and physiology. Given this, it may be surprising how little is known about the mechanism that zebrafish use to determine sex. While zebrafish are a gonochoristic species (having two sexes) that do not switch sex as adults, it was appreciated early on that sex ratios obtained from breeding lab domesticated lines were not typically a 1:1 ratio of male and female, suggesting that sex was not determined by a strict chromosomal mechanism. Here we will review the recent progress toward defining the genetic mechanism for sex determination in both wild and domesticated zebrafish.
摘要
在过去的几十年里，斑马鱼（Danio rerio）已成为研究脊椎动物发育和生理学的主要模式生物。考虑到这一点，人们可能会对斑马鱼确定性别的机制知之甚少感到惊讶。虽然斑马鱼是一种雌雄同体的物种（有两种性别），但成年后不会改变性别，但人们很早就发现，从养殖实验室驯化系获得的性别比例通常不是 1:1 的雄性和雌性比例，这表明性别不是由严格的染色体机制决定的。在这里，我们将回顾最近在野生和驯化斑马鱼中定义性别决定遗传机制的进展。
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